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| Expressions and clinical significance of plasma fibronectin-3 and pentraxin 3 of women with hypertensive disorder complicating pregnancy |
| Rugao People's Hospital, Nantong, Jiangsu Province, 226001 |
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Abstract To explore the expression levels and the clinical significance of ficolin-3 and pentraxin 3(PTX3) of pregnant women with hypertensive disorder complicating pregnancy(HDCP). Methods: A total of 153 pregnant women with HDCP admitted to hospital from October 2018 to October 2020 were collected in study group retrospectively. According to the pregnancy outcomes of the women, these women were divided into group A(128 cases with normal pregnancy outcomes) and group B(25 cases with adverse pregnancy outcomes). 132 healthy pregnant women were included in control group during the same period. The general data of the women were compared between the study group and the control group. Enzyme-linked immunosorbent assay(ELISA) was used to detect the plasma ficolin-3 and PTX3 levels of the women in these groups. Pearson method was used to analyze the correlation between the plasma ficolin-3 level of the women with HDCP and their PTX3 level. Logistic regression was used to analyze the effects of the plasma ficolin-3 and PTX3 levels of the women with HDCP on their adverse pregnancy outcomes. Receiver operating characteristic(ROC) curve was used to analyze the predictive value of the plasma ficolin-3 and PTX3 levels of the women with HDCP for their adverse pregnancy outcomes. Results: The expression of plasma ficolin-3(32.85±8.96μg/L) of the women in the study group was significantly higher than that(20.47±6.58μg/L) of the women in the control group, and the expression of PTX3 level(2.79±0.34μg/L) of the women in the study group was significantly lower than that(2.94±0.27μg/L) of the women in the control group. The plasma ficolin-3 level of the women in group B was significantly higher than that of the women in group A, and the PTX3 level of the women in group B was significantly lower(all P<0.05). The results of Pearson analysis showed that the plasma ficolin -3 of the women with HDCP was negatively correlated with their PTX3 level(r=0.369, P<0.05). The high expression of plasma ficolin -3 and the low expression of PTX3 of the women with HDCP were the risk factors of their occurred adverse pregnancy outcomes. The results of ROC curve analysis showed that the area under the curve(AUC) of the plasma ficolin-3 and PTX3 of the women for predicting their adverse pregnancy outcomes were 0.875 and 0.745, the cutoff value of which were 31.27 μg/L and 2.75 μg/L, the sensitivity of which were 82.8% and 61.7%, and the specificity of which were 84.0% and 80.0%. The AUC, the sensitivity and the specificity of combined plasma ficolin-3 and PTX3 levels of the women for predicting their adverse pregnancy outcomes were 0.904, 81.3% and 92.0%, respectively. Conclusion: The plasma Ficolin-3 level of the women with HDCP is highly expressed, while the PTX3 level is lowly expressed, and both of which are related to their adverse pregnancy outcomes and can be used as the potential biological indicators for predicting their pregnancy outcomes.
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