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| Effects of esketamine used for anesthesia during laparoscopic total hysterectomy of patients on their inflammatory factor levels and stress response |
| 1.Linhai Matermal and Child Health Hospital, Zhejiang, 317000; 2.Zhejiang Taizhou Hospital |
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Abstract To investigate the effects of esketamine used for anesthesia during laparoscopic total hysterectomy of patients on their inflammatory factor levels and stress response. Methods: 100 patients who wanted laparoscopic total hysterectomy were randomly divided into two groups(50 cases in each group) from July 2019 to July 2021. The patients in the control group received anesthesia induction by propofol combined with fentanyl, while the patients in the observation group consisted of 50 patients received anesthesia induction by propofol combined with esketamine, and the other anesthesia methods of the women in the two groups were the same. The vital signs, the inflammatory factor levels, the stress reactions, and the adverse reactions(respiratory depression, nausea and vomiting, chills, restlessness and delayed awakening) of the patients were compared between the two groups. Results: The values of the mean arterial pressure and heart rate of the patients in the two groups immediately before intubation, at 1min and 3min after intubation were significantly lower than those before anesthesia induction, but which of the patients in the observation group were significantly higher than those of the patients in the control group. The levels of serum interleukin-6 and tumor necrosis factor-α of the patients in the two groups after operation had increased significantly, and which(70.53±10.02 ng/L and 11.42±2.97 ng/L) of the patients in the observation group were significantly lower than those(96.24±12.84 ng/L and 17.93±4.48 ng/L) of the patients in the control group. The levels of cortisol, epinephrine and norepinephrine of the patients in the two groups after operation had increased significantly, and which(12.45±1.96μg/dl, 40.17±5.93 ng/L and 164.73±41.80 ng/L) of the patients in the observation group were significantly lower than those(16.27±2.11μg/dl, 54.16±7.22 ng/L and 181.95±50.65 ng/L) of the patients in the control group. The total incidence of adverse reactions(10.0%) of the patients in the observation group was significantly lower than that(26.0%) of the patients in the control group(P<0.05). Conclusion: Esketamine used for anesthesia during laparoscopic total hysterectomy of patients has good effectiveness, which can decrease the fluctuation of their haemodynamics, reduce the influence on their inflammatory factor levels, alleviate their stress reactions, and reduce their adverse reactions.
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