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| Effect of esketamine combined with propofol for anesthesia during induced abortion and its influence on the anxiety and depression of the women |
| The First Affiliated Hospital of Zhengzhou University, Henan Province International Joint Laboratory of Pain, Cognition and Emotion，Zhengzhou, Henan Province, 450000 |
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Abstract To investigate the effect of esketamine combined with propofol for anesthesia during painless abortion of women, and to study its influence on the anxiety and depression of the women. Methods: 80 pregnant women who wanted painless abortion were selected and were divided into two groups(40 cases in each group) according to the random number table from August 2022 to June 2023. The women in the observation group were given esketamine combined with propofol for anesthesia during abortion, and the women in the control group were given sufentanil combined with propofol for anesthesia during abortion. The dosage of propofol used, the induction time of anesthesia, the awakening time, the conservative time in hospital and the VAS score of the women were observed and were compared between the two groups. The anxiety(SAS) and depression(SDS) scales were used to measure the psychological status and resilience before abortion and in 1 week after abortion, and the quality of recovery of the women. Results: There were no significant differences in the dosage of propofol used, the induction time of anesthesia, the awakening time, the conservative time in hospital and the VAS score of the women between the two groups(P>0.05). In 1 week after abortion, the SAS and SDS scores of the women in the two groups had decreased significantly, and which(45.08±8.76 points and 44.93±8.26 points) of the women in the observation group were significantly lower than those(52.01±7.99 points and 50.15±6.71 points) of the women in the control group. The psychological resilience and recovery quality score of the women in the two groups had increased significantly, and which of the women in the observation group were significantly higher than those of the women in the control group(all P<0.05). Conclusion: Esketamine combined with propofol uses for anesthesia during abortion of the women, which can relieve the postoperative adverse emotions, such as anxiety and depression, and can improcve the quality of life of the women under the premise of satisfying the anesthetic effect. So, esketamine combined with propofol for anesthesia can be used as a feasible choice for the clinical optimization of anesthesia program.
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