To investigate the incidence of subchorionic hematoma (SCH) of pregnant women after in vitro fertilization and embryo transfer (IVF-ET), and to analyze the related influencing factors of SCH. Methods: The clinical data of 406 pregnant women who received assisted reproduction by IVF-ET from March 2019 to December 2021 were selected in the study. These women were divided into two groups according to whether SCH or not by B ultrasound imaging of the women during the first trimester of pregnancy, including the women with SCH in group A and the women without SCH in group B. The clinical data of the women were analyzed and compared between the two groups. The related factors affecting the occurrence of SCH of the women were analyzed by logistic regression model. Results: Among 406 women, there were 141 women in group A and 265 women in group B. There were significant differences in the type of infertility, the indexes values of coagulation function and immune function, the previous history of abortion, the multiparity history, and the causes of infertility of the women between the two groups (P<0.05). Multivariate logistic regression analysis showed that the secondary infertility (OR=1.690), the abnormal blood coagulation (OR=3.846), the immune abnormality (OR=4.899), the previous abortion history (OR=1.397), the multiparity history (OR=1.288), and the infertility caused by fallopian tubal factor (OR=2.065) of the pregnant women after IVF-ET were the independent factors affecting their SCH occurrence during the first trimester of pregnancy (all P<0.05). Conclusion: The risk factors affecting the SCH occurrence of the pregnant women should be paid close attention to and be given positive intervention, so as to wary of the SCH occurrence of the women during the first trimester of pregnancy after IVF-ET.