To compare the effects of epidural anesthesia and combined spinal-epidural on the labor process and the delivery outcomes of primiparas with full-term singleton. Methods: A total of 120 primiparas requiring labor analgesia in hospital were collected and were divided into two groups according to different anesthetic methods (60 cases in per group) from January 2021 to January 2023. The primiparas in group A were given epidural anesthesia and the primiparas in group B were given combined spinal-epidural anesthesia. Results: There were no significant differences in the visual analogue scale (VAS) score before analgesia and at 1 min after analgesia, the neonatal weight, the neonatal Apgar score at 1, 5, and 10 min after birth, the durations and bleeding amounts of the first, the second, the third stage of labor of the primiparas between the two groups (P>0.05). The onset time of analgesia, the VAS score after 3-15 min analgesia, the total duration of labor, the uterine recovery time, the rates of labor interference and adverse reactions of the primiparas in group A were 3.260.69 min, 306.9±42.4 min, 25.7±6.3d, 1.7%, and 1.7%), which were significantly lower than those (10.25±1.25 min, 331.8±49.5 min, 28.1±6.8 d, 13.3%, and 13.3%) of the primiparas in group B. The motor block rate of the primiparas in group A is significantly less than that of the primiparas in group B. The anesthetic effect of the primiparas in group A was significantly better than that of the primiparas in group B (all P＜0.05). Conclusion: Both the epidural anesthesia and the combined spinal-epidural can be used for labor analgesia of the primiparas with full-term singleton. Compared with those of the epidural anesthesia, the combining pinal epidural anesthesia has certain advantages in terms of analgesia onset time, shortening the labor process, promoting the uterine recovery, reducing the labor process interference, reducing the motor block, improving the anesthetic effect, and reducing the adverse reactions of the primiparas.