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| Efficacy of misoprostol combined with injection for preventing postpartum hemorrhageuterine because of uterine atony of women after cesarean section and its influence on the ovarian function |
| First People's Hospital of Shuangliu District, Chengdu, Sichuan Province, 610200 |
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Abstract To explore the efficacy of misoprostol combined with motherwort injection for preventing postpartum hemorrhageuterine because of uterine atony of women after cesarean section, and to study its influence on the ovarian function of these women. Methods: 92 pregnant women who wanted elective cesarean section were selected and were divided into group A (46 women with the treatment of oral misoprostol combined with leonurus injection) and group B (46 women with the treatment of oral misoprostol) according to the random number table method from May 2020 to July 2022. The clinical efficacy, the perioperative blood loss, the values of coagulation function, the ovarian function, and the adverse reactions rate of the women were compared between the two groups. Results: The incidence of postpartum hemorrhageuterine because of uterine atony (2.2%) of the women after cesarean section in group A was significantly lower than that (15.2%) of the women in group B. The amount of bleeding of the women in 2h or in 24h after cesarean section in group A (171.7±26.6 ml or 53.8±10.3 ml) was significantly lower than that (232.5±23.3 ml or 67.2±14.1 ml) of the women in group B. The amplitude of uterine fundal height decline of the women in the 3d or 5d after cesarean section in group A (4.0±0.4 cm or 5.3±0.7 cm) was significantly higher than that (3.7±0.4 cm or 4.8±0.6 cm) of the women in group B. The duration of lochia (14.1±2.4 d) of the women in group A was significantly shorter than that (16.4±3.6 d) of the women in group B. After treatment, the levels of PT, APTT, and FIB of the women in the two groups had increased significantly, and which of the women in group A was significantly higher than that of the women in group B. The levels of FSH and LH of the women in the two groups had decreased significantly, the E2 level of the women in the two groups had increased significantly, and the changes of which of the women in group A were significantly more than those of the women in group B. There was no significant difference in the total incidence of adverse reactions (6.5% vs. 13.0%) of the women between the two groups (P>0.05). Conclusion: Misoprostol combined with motherwort injection for preventing postpartum hemorrhageuterine because of uterine atony of the women after cesarean section can increase the efficacy of hemostasis, and can improve their blood coagulation and ovarian function.
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