|
|
|
| Correlation between the serum 25-hydroxyvitamin D level of women and their persistent high-risk human papilloma virus infection and its significance |
| 1.Nantong Second People's Hospital, Nantong, Jiangsu Province, 226002; 2 Nantong Maternal and Child Health Hospital; 3. Xianfeng Street Health Service Center, Tongzhou District, Nantong, Jiangsu Province |
|
|
|
|
Abstract To analyze the correlation between the serum 25-hydroxyvitamin D ［25-(OH) D］ level of women and their persistent high-risk human papilloma virus (HRHPV) infection. Methods: A total of 900 women with HR-HPV infection were selected in this study from June 2016 to May 2019. The serum 25-(OH) D level of these women was detected. The incidence of persistent HR-HPV infection of the women within 2 years of follow-up was counted. The data of these women were collected by the electronic medical record system, and 1:1 matching was performed between the women with persistent HR-HPV infection and the women without persistent HR-HPV infection according to the nearest matching method. The score of the women was calculated by logistic regression model. The correlation between the serum 25-(OH) D level of the women and their persistent HR-HPV infection was analyzed. Receiver operating characteristic (ROC) curve was drawn to analyze the value of 25-(OH) D level of the women for evaluating their persistent HR-HPV infection. Restricted cubic splines (RCS) model was used to analyze the nonlinear correlation between the serum 25-(OH) D level of the women and their persistent HR-HPV infection. Results: 900 women with HR-HPV infection were followed up for two years, and 685 women had been effectively followed up, with the follow-up rate of 76.1%. There were 103 women with persistent HR-HPV infection, with an incidence of 15.0%. After propensity score matching, there were significant differences in the cervicitis rate, the number of sexual partners, the family history of cervical cancer, the HPV typing, and the serum 25-(OH) D level between the women with persistent HR-HPV infection and the women without persistent HR-HPV infection (P<0.05). Logistic regression analysis showed that the serum 25-(OH) D level of the women was still an independent risk factor for their persistent HR-HPV infection after adjusting the confounding factors (P<0.05). The AUC value, the sensitivity, and the specificity of the serum 25-(OH) D level of the women for evaluating their persistent HR-HPV infection were 0.823, 70.6%, and 82.4%, respectively. There was a nonlinear dose-response relationship between the serum 25-(OH) D level of the women and their persistent HR-HPV infection rate (P=0.039), and the curve intersection point was located at 50 ng/ml. The 25-(OH) D level of the women with 25-(OH) D level≤50 ng/ml was negatively correlated with their persistent HR-HPV infection rate (β=-2.226, 95%CI 0.218-0.681, P=0.008). Conclusion: The serum 25-(OH) D level of the women is an independent protective factor for their persistent HR-HPV infection, which shows a nonlinear dose-response relationship with the persistent HR-HPV infection rate, and it can be used as the reference indicator to judge the risk of the persistent HR-HPV infection of the women.
|
|
|
|
|
|
|
|
|
