|
|
|
| Analysis of the efficacy and the related factors of missed diagnosis of colposcopy biopsy combined with thinprep cytology test for diagnosing cervical intraepithelial neoplasia |
| Xiaolan People's Hospital of Zhongshan, Guangdong Province, 528415 |
|
|
|
|
Abstract To investigate the diagnostic efficacy of colposcopy biopsy combined with thinprep cytology test(TCT) for diagnosing cervical intraepithelial neoplasia(CIN), and to analyze the related factors of the missed diagnosis of CIN. Methods: The clinical data of 89 patients who had been surgical treatment in department of gynecology from January 2019 to May 2022 were collected retrospectively. These patients had accepted colposcopy biopsy combined with TCT. The postoperative pathological result of the patients were as the gold standard for diagnosing their CIN, and the efficacies of the colposcopy biopsy, TCT, and the combined colposcopy biopsy and TCT of the patients for diagnosing their CIN were statistical analysis. The patients were divided in two groups according to the results of the combined colposcopy biopsy and TCT, including 10 patients with missed diagnosis of CIN in group A and 79 patients without missed diagnosis of CIN in group B. The risk factors of missed diagnosis of CIN were analyzed. Results: The pathological results showed that there were 71(79.8%) cases with positive CIN and 18(20.2%) cases with negative CIN. The colposcopy biopsy results showed that there were 57(64.0%) cases with positive CIN and the TCT results showed that there were 59(66.3%) cases with positive CIN. The colposcopy biopsy combined with TCT results showed that there were 64(71.9%) cases with positive CIN. The sensitivity and the specificity of colposcopy biopsy combined with TCT of the patients for screening their CIN were 86.7% and 80.5%. Multivariate analysis showed that the cervical lesion area <1/2 in colposcopy examination, only one colposcopy biopsy specimen, and the blurred colposcopic images of the patients were the risk factors for their missed diagnosis of CIN. Conclusion: The colposcopy biopsy combined with TCT of the patients for screening their CIN can increase the efficacy. The key to reduce the rate of missed diagnosis of CIN includes the improvement the colposcopic images quality and increase of the number of biopsy specimens in clinical application.
|
|
|
|
|
|
|
|
|
