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| Values of the expression levels of serum angiopoietin-2, human epididymal secretory protein 4, and insulin-like growth factor-1 of women with uterine fibroids for predicting their hysteroscopic postoperative recurrence of uterine fibroids |
| The Affiliated People's Hospital of Hubei University of Medicine, Hubei Province, 442000 |
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Abstract To investigate the values of the expression levels of serum angiopoietin-2 (Ang-2), human epididymal secretory protein 4 (HE4), and insulin-like growth factor1 (IGF-1) of women with uterine fibroids for predicting their hysteroscopic postoperative recurrence of uterine fibroids. Methods: 126 women with uterine fibroids who had treated with hysteroscopic surgery in hospital from January 2019 to October 2020 in study group were analyzed retrospectively. 100 healthy women who had been physical examination during the same period were selected in control group. The levels of the serum Ang-2, HE4, and IGF-1 were compared between the women in the study group before surgery and the women in the control group on the day of physical examination. The women in the study group were given postoperative follow-up for 1 year, and which were further divided in group A (women with the recurrence of uterine fibroids) and group B (women without the recurrence of uterine fibroids) based on the results of clinical imaging and pathological examination of the women. The levels of serum Ang-2, HE4, and IGF-1 of the women were compared between group A and group B. Pearson correlation analysis was used to analyze the correlation between the levels of serum Ang-2, HE4, and IGF-1 of the women in the study group and their recurrence of uterine fibroids after surgery. The values of Ang-2, HE4, and IGF-1 levels of the women in the study group for predicting their recurrence of uterine fibroids after hysteroscopic surgery were analyzed by operating characteristic curve (ROC). Results: The serum Ang-2, HE4 and IGF-1 levels of the women in the study group were significantly higher than those of the women in the control group, and which of 14 women in group A were significantly higher than those of 112 women in group B (all P＜0.05). The levels of serum Ang-2, HE4, and IGF-1 of the women in the study group were positively correlated with their postoperative recurrence (P＜0.05). The sensitivity of the levels of serum Ang-2, HE4, and IGF-1 of the women for predicting their postoperative uterine fibroids recurrence were 83.8%, 71.6%, and 51.4%, respectively, and the specificity of which were 78.8%, 75.0%, and 73.1%, respectively. The area under the curve, the sensitivity, and the specificity of the combined levels of serum Ang-2, HE4, and IGF-1 of the women for predicting their postoperative uterine fibroids recurrence were 0.906, 85.1%, and 86.5%, respectively. Conclusion: The expression levels of serum Ang-2, HE4, and IGF-1 of the women with uterine fibroids are abnormal, and the combined levels of serum Ang-2, HE4, and IGF-1 of the women for predicting their postoperative uterine fibroids recurrence has higher value.
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