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Abstract To explore the interaction between the expressions of serum lymphocyte subsets of patients with low ovarian reserve and their ovarian reserve function indicator. Methods: 82 patients with low ovarian reserve function were selected in study group and 50 health women confirmed by the physical examination were selected in control group from September 2020 to September 2022. The levels of serum lymphocyte subpopulation, such as CD3 +, CD4 +, and CD8 +, of the patients in both groups were detected. The CD4 +/CD8 + ratio of the patients in both groups was calculated. The levels of luteinizing hormone (LH), FSH (FSH), progesterone (P), testosterone (T), estradiol (E2), prolactin (PRL), inhibin B (INHB), and anti-seedling hormone (AMH) of the patients were compared between the two group. Ultrasound was used to examine the ovarian indexes of the patients in both groups. Results: The levels of CD3+ and CD8+ of the patients in the study group were significantly higher than those of the patients in the control group. The levels of CD4+ and the CD4+/CD8+ ratio of the patients in the study group were significantly lower than those of the patients in the control group. The levels of LH, FSH, and E2 of the patients in the study group were significantly higher than those of the patients in the control group. The levels of T, PRL, INHB, and AMH of the patients in the study group were significantly lower than those of the patients in the control group. The antral follicle counting, the number of follicles, the ovarian volume, the endometrial thickness, and the diastolic and systolic blood flow of ovarian artery of the patients in the study group were significantly lower than those of the patients in the control group (all P<0.05). Interaction analysis by linear regression method showed that the levels of CD3+, CD4+, and CD8+, the CD4+/CD8+ ratio of the patients had interaction with their levels of LH, FSH, P, T, E2, PRL, INHB, and AMH (△R2=0.983, P=0.000). There were interactions between the levels of CD3+, CD4+, and CD8+, and the CD4+/CD8+ ratio of the patients and their ovarian ultrasound indexes values (△R2=0.995, P=0.000). Conclusion: There is an interaction between the T lymphocyte subsets in the peripheral blood of the patients with low ovarian reserve function and their ovarian reserve function indicators. The patients with the increased levels of CD3+ and CD8+, or with the decreased levels of CD4+ and CD4+/CD8+ ratio are more likely to have lower ovarian reserve function.
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