To study the changes of serum human soluble FMS-like tyrosine kinase 1 (sFlt-1) and soluble endothelial factor (sEng) levels of pregnant women with pregnancy-induced hypertension (PIH), and to analyze their values for predicting the fetal growth restriction (FGR) of the women. Methods: 86 pregnant women with PIH diagnosed and delivered in hospital were selected in observation group from January 2020 to June 2022, including 25 women with FGR in group A and 61 women without FGR in group B. 86 normal pregnant women who underwent physical examination during the same period were selected in control group. The serum sFlt-1 and sEng levels of the women were compared between the observation group and the control group, and between group A and group B. Receiver operating characteristic (ROC) curve was used to analyze the efficacies of the serum sFlt-1 and sEng levels for predicting their FGR. Results: The levels of serum sFlt-1 (5358.16±52.25 pg/ml) and sEng (37.33±3.65 ng/L) of the women in the observation group were significantly higher than those (4166.01±52.99 pg/ml and 33.69±4.11 ng/L) of the women in the control group, and which of the women in group A were significantly higher than those of the women in group B (all P＜0.05). The diagnostic accuracy (83.7%) of the combined serum sFlt-1 and sEng levels of the women for FGR was significantly higher than that (67.4%) of the serum sFlt-1 level and that (73.3%) of the serum sEng level alone. The area under the curve (0.871) of the combined serum sFlt-1 and sEng levels of the women for FGR was significantly higher than that (0.792) of the serum sFlt-1 level and that (0.778) of the serum sEng level alone. Conclusion: The levels of serum sFlt-1 and sEng of the pregnant women with PIH increase abnormally. The combined serum sFlt-1 and sEng levels of the women for FGR have better predictive value.