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| Value of the examination by transvaginal ultrasonography s-Flow combined with the levels of serum anti cardiolipin antibody and anti-β2 glycoprotein Ⅰantibody of pregnant women during the first trimester of pregnancy for evaluating their adverse pregnancy outcomes |
| The Second People's Hospital of Hengshui, Hebei Province, 053000 |
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Abstract To investigate the value of the blood flow signal classification by vaginal bidirectional energy Doppler technique (s-Flow) combined with the detections of serum anti-cardiolipin antibody (ACA) and anti-β2-glycoprotein Ⅰ(anti-β2GPI) antibody of pregnant women during the first trimester of pregnancy for evaluating their adverse pregnancy outcomes. Methods: The clinical data of 320 pregnant women with threatened preterm labor or threatened abortion from June 2018 to June 2020 were collected. The blood flow signal classification of these women were examined by s-Flow, and the levels of serum ACA and anti-β 2 GPI antibody of these women were detected. According to the final pregnancy results, these women were divided into group A (241 cases with normal pregnancy outcome) and group B (79 cases with adverse pregnancy outcomes). Logistic regression was used to analyze the factors affecting the adverse pregnancy outcomes of the women. The predictive value of the blood flow classification by vaginal s-Flow, and the serum ACA and anti-β2GPI antibody levels of the women for the pregnancy outcomes was assessed by receiver operating characteristic (ROC) curve. Results: There was significant difference in the blood flow signal classification of the women between the two groups (P＜0.05). The serum ACA and anti-β2GPI antibody levels of the women in group B were significantly higher than those of the women in group A (P＜0.05). Logistic regression analysis showed that the blood flow signal classification by vaginal s-Flow, and the levels of serum ACA and anti-β2GPI antibody of the women were the independent risk factors of their adverse pregnancy outcomes (P＜0.05). The area under the curve of the blood flow signal classification by vaginal s-Flow of the women for evaluating their adverse pregnancy outcomes was 0.578. The area under the curve of the serum ACA level with the cut-off value >3.87mIU/ml of the women for evaluating their adverse pregnancy outcomes was 0.787. The area under the curve of the serum anti-β2GPI antibody level with the cut-off value >7.29 U/ml of the women for evaluating their adverse pregnancy outcomes was 0.745. The area under the curve, the sensitivity, and the specificity of the combined of the blood flow signal classification by vaginal s-Flow and the serum ACA and antiβ2GPI antibody levels of the women for evaluating their adverse pregnancy outcomes were 0.881, 81.0%, and 79.3%, respectively. Conclusion: The blood flow signal classification by vaginal s-Flow combined with the detections of the serum ACA and anti-β2GPI antibody of the pregnant women during the first trimester of pregnancy for evaluating their pregnancy outcomes has better efficacy.
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