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| Effects of the ovulation induction on the sex ratio of offspring after artificial insemination with donor |
| Hebei Provincial Reproductive Health Hospital, Hebei Key Laboratory of Reproductive Medicine, Shijiazhuang, Hebei Province, 050071 |
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Abstract To investigate the effects of the ovulation induction treatment and the different ovulation induction protocols on the sex ratio of offspring after artificial insemination with donor (AID). Methods: A retrospective analysis was performed on the data of 1,346 offspring of the women with singleton pregnancy and live birth after AID from January 2015 to December 2020. These women were included the cases with natural cycle (NC) in group A, and the cases with ovulation induction cycle (OIC) in group B according to whether the women received ovulation induction therapy or not. The women in group B were further divided into four subgroups according to the different ovulation induction protocols, including the women with clomifene citrate (CC) for ovulation induction in group B1, the women with CC combined with human menopause gonadotrophin (hMG) for ovulation induction in group B2, the women with letrozole (LE) for ovulation induction in group B3, and the women with LE combined with hMG for ovulation induction in group B4. The differences of the sex ratio of the offspring of the women were compared between group A and group B, and among group B1, B2, B3, and B4. Univariate and multivariate Logistics regression analysis were used to analyze the influence of the ovulation induction treatment and the ovulation induction protocols of the women on the sex ratio of their offspring after AID. Results: The sex ratio of the offspring in this study was 108.0. The sex ratio (108.2) of the offspring in group B had no significantly different from that (107.9) of the offspring in group A (P＞0.05). There was no significant difference in the sex ratio (107.9 vs.109.8 vs.105.3 vs.109.5) of the offspring after AID among groups B1, B2, B3, and B4 (χ2=0.05, P＞0.05). Multivariate logistic regression showed that the ovulation induction protocols of the women during AID had no impact on the sex ratio of their offspring (OR=1.00, 95%CI 0.929-1.073). Conclusion: The ovulation induction therapy and the ovulation induction protocols for treating the women during AID have not showed any impact on the sex ratio of their offspring.
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