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| Values of Finkler ultrasound score and the systemic immune inflammation index and the serum carbohydrate antigen 125 levels of elderly patients for diagnosing their ovarian cancer and the chemotherapy efficacy evaluation of the patients |
| Nanyang Central Hospital, Nanyang, Henan Province, 473000 |
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Abstract To investigate the values of Finkler ultrasound score, and systemic immune inflammation index (SII) and serum carbohydrate antigen 125 (CA125) levels of elderly patients for diagnosing their ovarian cancer, and to study the chemotherapy efficacy evaluation of the patients. Methods: 120 elderly patients with ovarian cancer were included in study group, and 60 patients with benign ovarian tumors were included in control group from January 2017 to March 2021. All the patients were examined by color Doppler ultrasound, and their SII and CA125 levels was detected before treatment. According to the duration of the tumor free survival of the patients in the study after the first chemotherapy, the patients were divided into group A (the patients with chemotherapy response) and group B (the patients without chemotherapy response). The diagnostic efficiencies of Finkler ultrasound score, and the SII and serum CA125 levels of the patients for their ovarian cancer were evaluated by receiver operating characteristic curve (ROC). Logistic regression analysis was used to identify the risk factors affecting the chemotherapy efficacy for threating the ovarian cancer of the patients. Results: Finkler ultrasound score, and the levels of SII and CA125 of the patients in the study group were significantly higher than those of the patients in the control group (all P<0.05). Finkler ultrasound score, the SII level, and the CA125 level, and the combination of Finkler ultrasound score and the SII and CA125 levels could be used for differential diagnosis of the benign and the malignant ovarian lesions of the patients. The combination of Finkler ultrasound score and the SII and CA125 levels of the patients had the highest sensitivity (91.3%) and the highest specificity (93.3%). After 24 months of follow-up, there were 71 patients in group A and 49 patients in group B with disease free survival (DFS) ≥6 months. The proportion of III-IV clinical stage of the ovarian cancer, the Finkler ultrasound score, the SII and CA125 levels of the patients in group B were significantly higher than those of the patients in group A (P<0.05). Logistic analysis showed that the clinical stage and the increased CA125 level were the independent risk factors for the chemotherapy response of the elderly patients with ovarian cancer (P<0.05). There were 36 (30.0%) dead patients and 84 (70.0%) survival patients, and the CA125 level of the dead patients was significantly higher than that of the survival patients (P<0.05). Conclusion: Finkler ultrasound score combined with the SII and CA125 levels of the patients can be used to differentiate their benign and malignant ovarian lesions. The clinical stage of the ovarian cancer and the increased CA125 level were the independent risk factors for the chemotherapy response of the elderly patients with ovarian cancer. The higher CA125 level of the patients has lower 2-year survival rate.
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