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| Diagnostic value of the combined detections of serum carcinoembryonic antigen, carbohydrate antigen 153, and carbohydrate antigen CA72 4 for endometrial carcinoma |
| Changxing Maternal and Child Health Care Hospital, Huzhou, Zhejiang Province, 313105 |
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Abstract To analyze the influences of the levels of serum carcinoembryonic antigen (CEA), carbohydrate antigen 153 (CA153), and CA72 4 of patients on their endometrial carcinoma, and to study their diagnostic values for the endometrial carcinoma. Methods: A total of 120 patients with endometrial cancer who were diagnosed and treated in hospital were selected in observation group, and 125 healthy volunteers were selected in control group from September 2020 to October 2022. The serum CEA level of the patients was measured by ELISA. The serum CA153 and CA72 4 levels of the patients were detected by chemiluminescence immunoassay. Pearson correlation analysis was performed on the correlation between the serum CEA, CA153, and CA72 4 levels of the patients in the observation group and their endometrial cancer occurrence. Logistic regression was used to analyze the factors affecting the occurrence of endometrial carcinoma. Receiver operator characteristic (ROC) curve was used to analyze the diagnostic value of the combined levels of CEA, CA153, and CA72 4 of the patients for their endometrial carcinoma. Results: The levels of CEA (9.27±3.05μg/L), CA153 (41.19±13.32 U/ml) and CA72 4 (11.58±3.61 U/ml) of the patients in the observation group were significantly higher than those (3.52±1.13μg/L, 15.76±4.84 U/ml, and 6.54±1.81 U/ml) of the patients in the control group. The levels of serum CEA, CA153, and CA72 4 of the patients were positively correlated each other, and the CA153 level of the patients was positively correlated with their CA72 4 level (P＜0.05). The serum CEA, CA153, and CA72 4 levels of the patients in the observation group were correlated with the TNM stages, differentiation, lymph node metastasis, muscular infiltration degree of their endometrial cancer (P＜0.05). Regression analysis showed that CEA, CA153, and CA72 4 of the patients were the risk factors for their endometrial cancer (P＜0.05). The area under the curve (AUC) of the combined levels of CEA, CA153, and CA72 4 (0.975) of the patients for diagnosing their endometrial cancer was significantly higher than that of CEA level, CA153 level, or CA72 4 level alone (P＜0.001). Conclusion: The serum CEA, CA153, and CA72 4 levels of the patients with endometrial carcinoma are elevated abnormally, which is related to the clinicopathological features of the patients, and the combinations of the serum CEA, CA153, and CA72 4 levels of the patients has higher diagnostic efficacy for their endometrial carcinoma.
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