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| Correlation between the antibody titer of IgG anti-A (B) of pregnant women with O blood type and the hemolytic disease of their newborn and their neonatal hyperbilirubinemia and its predictive value |
| Bozhou People's Hospital, Bozhou, Anhui Province, 236800 |
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Abstract To explore the significance of the antibody titer of IgG anti-A (B) of pregnant women with O blood type, and to study the value of the antibody titer of IgG anti-A (B) for predicting the hemolytic disease of the newborn (HDN) and the neonatal hyperbilirubinemia. Methods: The clinical data of 98 pregnant women with O blood type from January 2020 to June 2022 were collected retrospectively. The blood type and the antibody titer of these women had been detected. The expression of the antibody titer of IgG anti-A (B) and the incidence of HDN confirmed were compared between the women with O blood type and the women without O blood type. The correlation between the antibody titer of IgG anti-A (B) of the women with O blood type and their neonatal HDN and hyperbilirubinemia, and the predictive value of the antibody titer of IgG anti-A (B) for the neonatal HDN and hyperbilirubinemia were analyzed. Results: The proportions of the antibody titer of IgG anti-A and IgG anti-B ≤1:32 of the pregnant women with O blood type were 69.4% and 62.2%, which were significantly higher. The proportion of the emission positive cases (14.6%) in the neonates with HDN was significantly higher than that (7.3%) of the free positive cases in the neonates with HDN. The incidences of the neonatal HDN and hyperbilirubinemia were positively correlated with the maternal antibody titer. The higher maternal antibody titer was, the higher incidences of neonatal hemolytic disease and hyperbilirubinemia were (all P＜0.05). The areas under the curve of the receiver operating characteristic (ROC) curve of the combined antibody titer of IgG anti-A (B) of the women for evaluating their neonatal HDN and hyperbilirubinemia occurrences were 0.896 and 0.881, and the efficacy of which were significantly higher than that of the antibody titer of IgG anti-A or IgG anti-B alone (P＜0.05). Conclusion: The antibody titer of IgG anti-A (B) of the pregnant women with O blood type has correlation with their neonatal HDN and hyperbilirubinemia, and which has better predictive value for their neonatal HDN and hyperbilirubinemia. It is suggests that the antibody titer of IgG anti-A (B) of the pregnant women should be observed, and early intervention should be conducted.
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