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| Predictive value of the levels of serum Fibulin 3 and angiopoietin 2 of pregnant women during the first trimester of pregnancy for their hypertensive disorders of pregnancy |
| Hainan Modern Women and Children's Hospital, Haikou, Hainan Province, 571100 |
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Abstract To explore the predictive value of the levels of serum Fibulin 3 and angiopoietin 2(Ang 2) of pregnant women during the first trimester of pregnancy for their hypertensive disorders of pregnancy(HDP). Methods: A total of 118 pregnant women with HDP were selected in observation group from April 2020 to April 2022, and according to the severity of HDP, these women were divided 54 women with gestational hypertension in group A, 43 women with mild eclampsia in group B, and 21 women with severe eclampsia in group C. The adverse pregnancy outcomes of the women in the observation group were recorded. In addition, 120 healthy pregnant women with singleton pregnancy who accepted antenatal examination were selected in control group during the same period. Enzyme linked immunosorbent assay was used to detect the serum Fibulin 3 and Ang 2 levels of these women during the first trimester of pregnancy. Receiver operating characteristic curve(ROC) was used to evaluate the diagnostic value of the levels of serum Fibulin 3 and Ang 2 of the women for their HDP. Pearson Correlation analysis was conducted to explore the correlation between the levels of serum Fibulin 3 and Ang 2 of the women and their adverse pregnancy outcomes. Results: The levels of serum Fibulin 3(54.26±9.75 ng/ml) and Ang 2(12.52±3.56 ng/ml) of the women in the observation group were significantly lower than those(80.95±10.33 ng/ml and 18.22±3.98 ng/ml) of the women in the control group, and which of the women in group A, in group B, and in group C had decreased gradually(all P<0.05). ROC curve analysis showed that the area under the curve(AUC) of the serum Fibulin 3 level and the Ang 2 level of the women for predicting their HDP were 0.859 and 0.873, the cutoff values of which were 67.87ng/ml and 30.68ng/ml, the specificity of which were 63.1% and 69.6%, and the sensitivity of which were 92.4% and 92.4%. The AUC, the specificity, and the sensitivity of the combined levels of Fibulin 3 and Ang 2 of the women for predicting their HDP were 0.906, 87.2%, and 89.5%, respectively. In the observation group, the levels of serum Fibulin 3 and Ang 2 of the women with adverse pregnancy outcomes were significantly lower than those of the women with normal pregnancy outcomes. The levels of serum Fibulin 3 and Ang 2 of the women were negatively correlated with their fetal growth restriction, fetal distress, fetal distress, and neonatal death(all P<0.05). Conclusion: The serum Fibulin 3 and Ang 2 levels of the pregnant women with HDP decrease, which are related to the severity of HDP and the adverse pregnancy outcomes of the women. The combined serum Fibulin 3 and Ang 2 levels of the women for predicting their HDP has higher value.
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