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| Correlation between the levels of anti mullerian hormone and estradiol of women and their risk of oocyte maturation defect |
| Xuchang Maternity and Child Health Care Hospital, Xuchang, Henan Province, 461000 |
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Abstract To analysis the correlation between the levels of anti mullerian hormone(AMH) and estradiol(E2) of women and their risk of oocyte maturation defect(OMD). Methods: The clinical data of 106 women with OMD who had received conventional in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI) from February 2018 to September 2020 were enrolled in observation group. Another 120 women with normal fertilization were selected in control group. The age, the value of body mass index(BMI), and the levels of AMH and sex hormone of the women in the two groups were counted. Multivariate logistic regression analysis was performed to analyze the risk factors affecting OMD. Results: The levels of basic luteinizing hormone, follicle stimulating hormone, E2, and AMH of the women in the observation group were significantly lower than those of the women in the control group, while the levels of basic prolactin and progesterone of the women in the observation group were significantly higher(all P＜0.05). Regression analysis showed that the decrease of the basal E2 level was a risk factor of OMD. The immature oocyte was mostly the mixed block of 30.2%. There were 253 cycles with eggs obtained from 106 women with OMD, and 57.7% of the eggs were normal in morphology, and abnormal eggs included hyaline zona pellucida, abnormal zona pellucida thickness, abnormal color, abnormal periovular space, and absence of zona pellucida. 25.7% of eggs cell in cycle were associated with vacuole stage. The abnormalities situation of 16.6% of oocyte included large vacuoles in oocytes and oocyte fragmentation, etc. Conclusion: The lower basic E2 may increase the risk of OMD of the women.
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