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| Clinical characteristics of patients with ovarian endometriosis cyst recurrence and the efficacy of gonadotropin-releasing hormone agonist combined with laparoscopic surgery for treating these patients |
| 1. Shulan (Hangzhou)Hospital, Hangzhou, Zhejiang Province, 310000; 2. Fuyang Hospital of Traditional Chinese Medicine of Hangzhou；3.Shulan (Quzhou)Hospital |
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Abstract To analyze the clinical characteristics of patients with ovarian endometriosis cyst (OEC)recurrence, and to study the efficacy of gonadotropin-releasing hormone agonist (GnRH-a)combined with laparoscopic surgery for treating the patients with OEC recurrence. Methods: From May 2019 to May 2021, 24 patients with OEC recurrence after laparoscopic surgery were included in study group, and 80 patients without OEC recurrence were included in control group. The clinical characteristics of the patients in the two groups were observed. In addition, the patients in the study group were divided into the group A (12 patients with treatment of laparoscopic surgery)and group B (12 patients with treatment of laparoscopic surgery combined with VEGF). The sex hormones levels, the menstruation, and the clinical efficacy of the patients were compared between group A and group B. Results: Logistic regression model analysis showed that the bilateral cystic wall, the R-AFS stage Ⅲ to Ⅳ of OEC, and the thick cystic wall of the patients with OEC were their independent risk factors of the postoperative recurrence of OEC (P＜0.05). After treatment, the levels of estradiol, follicle stimulating hormone, and luteinizing hormone of the patients in the study group had decreased significantly, but the improvement of which of the patients in group B was significantly better than those of the patients in group A. The score of menstrual pain degree (3.2±0.9 points)of the patients in group B was significantly lower than that (5.3±1.3 points)of the patients in group A, and the total clinical effective rate (100.0%)of the patients in group B was significantly higher than that (66.7%)of the patients in group A (all P＜0.05). Conclusion: The lateral classification of the cystic wall, R-AFS stage of OEC, and the thickness of the cystic wall of the patients are all infecting their postoperative recurrence of OEC. The combined treatment of GnRH-a and laparoscopic surgery can significantly improve the levels of sex hormones and alleviate menstrual pain of the patients, with better clinical efficacy.
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