|
|
|
| Clinical value of the vitamin D level combined with the anti-Müllerian hormone level for predicting the pregnancy outcomes of infertile patients after in vitro fertilization-embryo transfer |
| Luoyang Central Hospital Affiliated to Zhengzhou University, Henan Province, 471300 |
|
|
|
|
Abstract To explore the clinical value of the vitamin D level combined with the anti-Müllerian hormone (AMH) level for predicting the pregnancy outcomes of infertile patients after in vitro fertilization-embryo transfer (IVF-ET). Methods: The clinical data of 402 infertile patients who had undergone IVF-ET from May 2019 to December 2021 were analyzed retrospectively. According to the pregnancy outcomes after IVF-ET, these patients were divided into group A (220 patients with clinical pregnancy) and group B (182 patients without clinical pregnancy). The levels of serum vitamin D and AMH of the patients in the two groups were detected after admission. Receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of the serum vitamin D and AMH levels of the patients for their pregnancy outcomes after IVF-ET. The influencing factors of the pregnancy outcomes of the infertile patients after IVF-ET were analyzed by multivariate logistic regression analysis. Results: The serum vitamin D and AMH levels of the patients in group B were significantly lower than those of the patients in group A (all P＜0.05). ROC curve showed that the areas under curve of the serum vitamin D level and the AMH level of the patients for predicting their pregnancy outcomes after IVF-ET were 0.768 and 0.816, the cut-off values of which were 5.86ng/ml and 15.10ng/ml, the sensitivity of which were 93.2% and 93.2%, and the specificity of which were 54.2% and 67.6%. The area under curve, the sensitivity, and the specificity of the combined levels of serum vitamin D and AMH of the patients for predicting their pregnancy outcomes after IVF-ET were 0.892, 86.3%, and 85.3%, respectively. Multivariate logistic regression analysis showed that the low serum vitamin D level, the low AMH level, the low fertilization rate, and the advanced age of the infertility patients were all the factors affecting their pregnancy after IVF-ET (P＜0.05). Conclusion: Both the serum vitamin D level and the AMH level of infertile patients without pregnancy after IVF-ET are low, and the combined levels of serum vitamin D and AMH of the patients can be as the effective indicators for predicting their pregnancy outcomes after IVF-ET.
|
|
|
|
|
|
|
|
|
