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| Analysis of the drug resistance of vaginal Escherichia coli and the drug resistance genes of producing extended spectyum β-lactamases bacterial strain of pregnant women during the third trimester of pregnancy |
| Ruian People's Hospital, Ruian, Zhejiang Province, 325200 |
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Abstract To analyze the drug resistance of vaginal Escherichia coli (E. coli), and to detect the drug resistance genes of producing extended spectyum β-lactamases bacterial strain (ESBLs) of pregnant women during the third trimester of pregnancy. Methods: The samples vaginal secretions of the pregnant women during the third trimester of pregnancy were collected to detect the E. coli strains and to analyze the drug resistance of clinical antibiotics used commonly and the drug resistance genotypes from January 2022 to September 2022. Results: 298 strains of vaginal E. coli of the pregnant women during the third trimester of pregnancy had been obtained, which were sensitive to carbapenems, β-lactamase inhibitors, and aminoglycosides (amicacin) was 98.0% to 100.0%, but the higher resistant of which to penicillin, cephalosporin, sulfonamides, and quinolones was 72.8% to 38.9%. The positive detection rate of ESBLs was 47.7% (142/298 cases). The resistance rate of ESBLs-positive strains to penicillin, cephalosporins, monoamides, aminoglycosides, quinolones, sulfonamides, and other antibiotics was significantly higher than that of ESBLs-negative strains (P＜0.05). The drug-resistant genotypes of 142 strains (47.7%) EsBLS-producing E. coli were CTX-M (81.7%), TEM-1 (59.2%), SHV (21.1%), and OXA (2.1%). The genotype combinations were mainly CTXM-15 and TEM-1 (21.8%), CTXM-15 and TEM-1 (20.4%), and CTXM-15 (13.4%). The resistance rate for cefotaxime (CTX) of producing ESBL of E. coli of CTX-M type was significantly higher in than that of TEM type or SHV type. The resistance rate for ceftazidime (CAZ) of producing ESBL of E. coli of CTX-M type was significantly lower than that of type or SHV type (all P＜0.05). There was no significant difference in the resistance rate for other antibiotics of producing ESBL of E. coli among CTX-M type, TEM type, and SHV type (P＞0.05). Conclusion: The producing ESBLs strains of vaginal E. coli from the pregnant women during the third trimester of pregnancy are mainly TEM-1, CTX-M-15, and CTX-M-14. The treatments of vaginal E. coli by penicillin, cephalosporin, sulfonamides, and fluoroquinolones should be cautious in clinic.
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