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| Effect of uterine isthmus ligation combined with low dose vasopressin by fractional injection of patients during laparoscopic excision of hysteromyoma |
| Huainan Chaoyang Hospital, Huainan, Anhui Province, 232000 |
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Abstract To observe the application effect of isthmus ligation combined with low-dose vasopressin by fractional injection of patients during laparoscopic excision of hysteromyoma, and to study its influence on the microcirculation of these patients. Methods: From January 2019-May 2022, 66 patients with laparoscopic excision of uterine fibroids were selected and were divided into two groups (33 cases in each group) by random single-blind drawing. The patients in the control group received traditional suture hemostasis combined with pituitary by one-time injection during the operation, and the patients in the observation group received uterine isthmus ligation combined with low-dose vasopressin by fractional injection during operation. The hemostatic efficacy, the surgical conditions, the changes of microcirculation indexes, such as diastolic blood pressure (DBP), systolic blood pressure (SBP), and heart rate (HR) before and after treatment, and the complications situation of the patients were compared between the two groups. 3 months of follow-up after treatment, the menstrual situation of the patients in the two groups were counted. Results: The intraoperative blood loss (52.6±7.9ml), the postoperative anal exhaust time (1.6±0.6d), and the hospitalization stay (4.7±1.1d) of the patients in the observation group were significantly shorter than those (74.3±9.6ml, 2.1±0.7d, and 6.0±1.3d) of the patients in the control group. The values of DBP, SBP, and HR of the patients in both groups after 15 min of treatment had increased significantly, and which (74.3±5.4 mmHg, 110.3±9.1 mmHg, and 75.5±4.6 times/min) of the patients in the observation group were significantly lower than those (78.0±6.1 mmHg, 117.0±10.0) mmHg, and 80.9±5.3 times /min) of the patients in the control group (P＜0.05). The total effective rate of hemostasis (97.0%) of the patients in the observation group was significantly higher than that (75.8%) of the patients in the control group (all P＜0.05). There was no significant difference in the incidence of postoperative complications (18.2% vs. 24.2%) of the patients between the two groups (P＞0.05). 3 months after treatment, the menstrual volume and menstrual period of the patients in both groups had decreased significantly, and which (46.1±2.2ml and 4.7±1.3d) of the patients in the observation group were significantly lower than those (52.7±3.1ml and 6.3±1.4d) of the patients in the control group (P＜0.05). Conclusion: The application of isthmus ligation combined with lowdose vasopressin by fractional injection of the patients during laparoscopic excision of uterine fibroids improves their hemostasis effect, is beneficial to the operation, promotes the recovery of the patients, and has less impact on the microcirculation system of the patients.
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