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| Value of the D-dimer/platelet value and the inhibitor of angiogenesis protein 1 level of women for predicting their abnormal uterine bleeding after medical abortion |
| Danzhou People's Hospital, Danzhou, Hainan Province, 571700 |
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Abstract To explore the D-dimer/platelet (DPR) value and the angiogenesis inhibitory protein 1 (VASH-1) level of women after medical abortion, and its predictive value for the abnormal uterine bleeding of the women. Methods: A total of 123 pregnant women who wanted medical abortion were selected and were divided into group A (21 cases with abnormal uterine bleeding) and group B (102 cases without abnormal uterine bleeding) according to the situation of uterine bleeding from March 2019 to March 2022. The levels of the plasma D-dimer and platelets, and the serum VASH-1 of the women before abortion in the two groups were detected, and their DPR was calculated. The predictive value of the DPR and the VASH-1 level of the women after abortion for their abnormal uterine bleeding were evaluated by receiver operating characteristic curve (ROC). The related factors of the abnormal uterine bleeding of the women were analyzed by multivariate logistic regression. Results: The DPR (0.85±0.31×10-11 mg) and the VASH-1 level (567.32±84.15 ng/L) of the women in group A were significantly higher than those (0.57±0.24×10-11 mg and 319.64±68.53ng/L) of the women in group B (P＜0.05). There were significant differences in the abortion history, and the fibrinogen, D-dimer, and platelet levels of the women between the two groups (P＜0.05). ROC curve analysis showed that the area under the curve (AUC) of the DPR and the VASH-1 level for diagnosing abnormal uterine bleeding of the women after medical abortion were 0.852 and 0.809, the cut-off values of which were 0.71×10-11 mg and 323.48ng/L, the specificity of which were 62.2% and 53.6%, and the sensitivity of which was 93.5% and 93.5%. The AUC, the specificity, and the sensitivity of the combined of the DPR and the VASH-1 level for diagnosing abnormal uterine bleeding of the women after medical abortion were 0.904, 85.3%, and 87.1%, respectively. Multivariate analysis showed that the history of abortion, the fibrinogen level >4g/L, the high DPR value and the VASH-1 level of the women were the risk factors of their abnormal uterine bleeding after medical abortion (P＜0.05). Conclusion: The DPR and the VASH-1 level of the women with abnormal uterine bleeding after medical abortion are high, which can be used as the reference indexes for predicting their abnormal uterine bleeding.
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