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| Analgesia and sedation effect of different doses of remimazolam tosylate of patients during painless abortion and its influence on the stress response of these patients |
| The First People's Hospital of Liangshan Yi Autonomous Prefecture, Xichang, Sichuan Province, 615000 |
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Abstract To explore analgesia and sedation effect of different doses of remimazolam tosylate of patients during painless abortion, and to study its influence on the stress response of these patients. Methods: 60 patients who were scheduled to have painless abortion in the hospital were enrolled and were divided into group A (20 patients with 5 mg of remimazolam tosylate combined with sufentanil for analgesia and sedation), group B (20 patients with 7 mg of remimazolam tosylate combined with sufentanil for analgesia and sedation), and group C (20 patients with 8 mg of remimazolam tosylate combined with sufentanil for analgesia and sedation) according to the random number table method between June 2020 and December 2020. The perioperative indicators, the stress reaction indicators, such as heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR), and oxygen saturation (SpO2), the analgesia and sedation effect, such as modified observer’s assessment of alertness/sedation (MOAA/S), the pain degree by visual analogue scale (VAS), and the occurrence of adverse reactions of the patients at different time points were compared among the three groups. Results: There were no significant differences in the operation time and the hospital stay of the patients among the three groups (P＞0.05). The awakening time (8.0±1.2 min), the total dose of remimazolam tosylate (13.1±1.6 mg), and the times of supplemental remimazolam tosylate (3.2±0.9 times) of the patients in group A were significantly higher than those (7.1±1.3 min, 11.2±1.4 mg, and 1.7±0.5 times) of the patients in group B and those (7.1±1.3 min, 11.6±1.4 mg, and 1.5±0.5 times) of the patients in group C (P＜0.05). The valus of HR, MAP, RR, and SpO2 of the patients in the three groups at T1 and T2 were significantly lower than those at T0 (P＜0.05). The MOAA/S score of the patients in the three groups had decreased gradually with the prolonging of the drugs administration, and which of the patients in group A, group B, and group C at each time point had decreased gradually (all P＜0.05). The VAS scores of the patients in the three groups had decreased gradually with the prolonging of the awakening time (all P＜0.05), but which of the patients had no significant differences among the three groups. There was no significant difference the incidence of the adverse reactions (10.0% vs.5.0% vs. 5.0%) of the patients among the three groups (P＞0.05). Conclusion: 7 mg remimazolam tosylate combined with initial sufentanil administration during painless abortion of the patients has definite anesthesia effect and has complete analgesia, and which has rapid postoperative awakening, with safety and effectiveness.
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