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| Effects of phloroglucinol or estradiol valerate combined with misoprostol on removal of IUD in postmenopausal women over 2 years |
| Hangzhou Women’s Hospital, Hangzhou , Zhejiang Province, 310008 |
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Abstract To investigate and compare the effects of phloroglucinol and estradiol valerate both of which combined with misoprostol, respectively, applied in women with menopause over two years who had the surgical evacuation of an intrauterine device (IUD). Methods: 80 women with menopause of 2-6 years who had the surgical evacuation of IUD and visited our outpatient clinic from November 2019 to March 2022 were selected as our observation subjects. These women were divided into two groups, one is phloroglucinol combined with sublingual misoprostol group (hereafter, the observation group) and another is estradiol valerate combined with sublingual misoprostol group (hereafter, the control group). Parameters including the degree of cervical softening, pain scores（VAS）, operation time, smooth degree of operation, intraoperative blood loss, discomfort degree，etc. were compared for the two groups accordingly. Results: After the removal of IUD, the total softening degree of the cervix in the observation group (100%) is higher than that in the control group (95.0%)，the VAS in the observation group（2.2）is better than that in the control group（3.1）, the mean operation time in the observation group (12.5 minutes) is shorter than that in the control group (17.5 minutes), the occurrence rate of difficulty in removing IUD in the observation group (65.0%) is lower than that in the control group (87.5%), the incidence of severe induced abortion syndrome during operation in the observation group（7.5%）is lower than that in the control group (17.5%), indicating these differences between the two groups are of statistically significant (P < 0.05). The intraoperative mean blood losses are 8.0mL and 9.1mL in the observation group and the control group, respectively, indicating the difference is of no statistically significant (P > 0.05). Conclusions: The results show that the application of phloroglucinol injection combined with sublingual misoprostol in women with menopause over two years is able to reduce the occurrence rate of difficulty in removing IUD, the incidence of severe induced abortion syndrome during operation and the operation time, indicating this method is worthy of clinical popularization.
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