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| Efficacy of hysteroscopic electrocision combine with progesterone for treating patients with endometrial polyps and its influence on the levels of estrogen and progesterone receptor expressions and the inflammatory factors of these patients |
| Jiangyou People’s Hospital，Jiangyou, Sichuan Province, 621700 |
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Abstract To explore the efficacy of hysteroscopic electrocision combined with progesterone intrauterine system (IUS) for treating patients with endometrial polyps, and to study its influence on the levels of estrogen and progesterone receptor expressions and the inflammatory factors of these patients. Methods: A total of 142 patients with endometrial polyps were selected and randomly divided into two groups (71 cases in each group) from January 2018 to January 2020. The patients in the control group were given hysteroscopic resection of endometrial polyps, and the patients in the observation group were given hysteroscopic resection of endometrial polyps and IUS inserted. The different levels of estrogen receptor (ER), progesterone receptor (PR), and the levels of inflammatory factors, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), C-reactive protein (CRP) of the patients before and after treatment were compared between the two groups. Results: In the sixth month after surgery, the score of menstrual blood loss map, the menstrual cycle, and the endometrial thickness of the patients in both groups had decreases significantly, the hemoglobin level of the patients in both groups had increases significantly, and the change ranges of which of the patients in the observation group were significantly more than those of the patients in the control group. The expression levels of PR and ER (0.94±0.43 and 1.66±0.60) of the patients in the observation group were significantly lower than those (1.50±0.62 and 1.94±0.74) of the patients in the control group. The levels of inflammatory factors, such as IL-6, TNF-α, IFN-γ, and CRP of the patients in both groups after surgery had decreased significantly, and which of the patients in the observation group were significantly lower than those of the patients in the control group (all P＜0.05). The recurrence rate (2 cases, 2.8%) of the patients in the observation group was significantly lower than that (11 cases, 15.5%) of the patients in the control group (P＜0.05). Conclusion: Hysteroscopic resection combined with IUS for treating endometrial polyps of the patients can effectively regulate the expression of their estrogen and progesterone receptors after surgery, and can reduce their level of inflammatory factors and their recurrence of endometrial polyps.
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