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| Prediction value of the levels of D dimer, folic acid, and coagulation function indexes during pregnancy for recurrent spontaneous abortion |
| Suining Central Hospital, Suining, Sichuan Province, 629000 |
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Abstract To study the diagnostic value of D dimer (D-D), folic acid, and coagulation function indexes for recurrent spontaneous abortion (RSA) during pregnancy. Methods: A total of 52 pregnant women with RSA during the first trimester of pregnancy were selected in the study group between January 2020 and January 2022. According to the occurrence of abortion of the women within 14 gestational weeks, these women were divided into group A (30 cases without spontaneous abortion) and group B (22 cases with spontaneous abortion). The levels of D-D, folic acid in red blood cells, plasma folic acid, and fibrinogen (Fbg), and the values of prothrombin time (PT), thrombin time(TT), and activated partial thromboplastin time (APTT) of the women were compared between the two groups, and the diagnostic value of which for recurrent spontaneous abortion was analyzed. Results: The proportion of the number of RSA ≥4 times (68.2%) and the D-D level (429.23 ±52.78 mu g/L) of the women in group B were significantly higher than those (36.7% and 392.51 ±51.12 mu g/L) of the women in group A. The levels of folic acid in red blood cells (428.71±120.52 ng/ml) and plasma folic acid (7.32±3.28 ng/ml) of the women in group B were significantly lower than those (492.68±122.41ng/ml and 9.34±3.87ng/ml) of the women in group A (P＜0.05). There were no significant differences in the values of Fbg, PT, TT, and APTT of the women between the two groups (P>0.05). Logistic regression analysis showed that the levels of -D and folic acid in red blood cells and in plasma were the influence factors of RSA. The maximum area under curve (AUC), the sensitivity, and the specificity of levels of folic acid in red blood cells and plasma for diagnosing RSA were 0.718, 45.5%, and 90.0%, respectively. The AUC, the sensitivity, and the specificity of the combined of the levels of D-D and folic acid, and the coagulation function for diagnosing RSA were 0.626, 31.8%, and 93.3%, respectively. Conclusion: The combined detections of D-D, folic acid, and coagulation function of the pregnant women with RSA for diagnosing their RSA again has certain value, with the higher specificity, but which has the risk of missed diagnosis of RSA.
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