|
|
|
| Serum forkhead box protein A1 and tumor necrosis factor receptor-associated factor levels of pregnant women with preeclampsia and their predictive value for the pregnancy outcomes of these women |
| Jiangning Hospital Affiliated to Nanjing Medical University/Nanjing Jiangning Hospital, Jiangsu Province, 211100 |
|
|
|
|
Abstract To investigate the serum levels of forkhead box protein A1 (FOXA1) and tumor necrosis factor receptor-associated factor 6 (TRAF6) of pregnant women with preeclampsia (PE), and to study their predictive value for the pregnancy outcomes of these women. Methods: The clinical data of 164 pregnant women with PE who had given birth from January 2019 to January 2022 were selected in study group. These women were divided into group A (women with mild PE) and group B (women with severe PE) according to the severity of PE. These women were also divided into group C (women with adverse pregnancy outcomes) and group D (women with normal pregnancy outcomes) according to the pregnancy outcomes of the women. Another 60 healthy pregnant women who underwent physical examination and gave birth were selected in control group. The clinical data, the levels of serum FOXA1 mRNA, TRAF6 mRNA, troponin I (cTnI), anticardiolipin antibody (ACA)-IgM, and ACA-IgG of these women were analyzed. Pearson correlation coefficient was performed to analyze the correlation among the different indicators. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of the levels of the serum FOXA1 mRNA and TRAF6 mRNA of the women with PE for their adverse pregnancy outcomes. Multivariate logistic regression was performed to analyze the factors affecting the adverse pregnancy outcomes of the women with PE. Results: The values of systolic blood pressure and diastolic blood pressure, and the levels of 24h urine protein, cTnI, ACA-IgM, and ACA-IgG of the women in control group, in group A and group B had increased successively, and the level of serum TRAF6 mRNA of the women in control group, in group A, and in group B had increased successively, which was 0.99±0.10, 1.58±0.22, and 1.97±0.26, respectively. The level of serum FOXA1 mRNA of the women in control group, in group A, and in group B had increased successively, which were 1.02±0.11, 0.69±0.09, and 0.56±0.08, respectively (all P＜0.05). The levels of cTnI, ACA-IgM, and ACA-IgG, and the values of systolic and diastolic blood pressure, and 24 h urinary protein of the women in groups A and B were negatively correlated with their FOXA1 mRNA level, and was positively correlated with their TRAF6 mRNA level (P＜0.05). The values of systolic and diastolic blood pressure, 24 h urine protein, and the levels of serum TRAF6 mRNA, cTnI, ACA-IgM, and ACA-IgG of the women in group C were significantly higher than those of the women in group D, and the serum FOXA1 mRNA level of the women in group C was significantly lower than that of the women in group D (P＜0.05). The area under curve (AUC) of the serum FOXA1 mRNA, TRAF6 mRNA, and the combination of serum FOXA1 mRNA and TRAF6 mRNA levels of the women with PE for predicting their adverse pregnancy outcomes were 0.824, 0.766, and 0.889, respectively. The increases of 24h urinary protein, TRAF6 mRNA, and ACA-IgG, and the decreases of FOXA1 mRNA of the women with PE were the independent influencing factors of their adverse pregnancy outcomes (P＜0.05). Conclusion: The levels of serum FOXA1 mRNA and TRAF6 mRNA of the pregnant women with PE are abnormal and are related to their severity of PE and their adverse pregnancy outcomes, which have value for predicting their adverse pregnancy outcomes, and the combination of the serum FOXA1 mRNA and TRAF6 mRNA levels have higher predictive value.
|
|
|
|
|
|
|
|
|
