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| Expression of serum miRNA-144 of women with missed abortion and its correlation with the hormone level |
| Jiangning Hospital of Nanjing, Jiangsu Province, 211100 |
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Abstract To study the expression of serum miRNA-144 of women with missed abortion, and to study its correlation with hormone level of the women during pregnancy. Methods: A prospective research was conducted in this study. 112 women with missed abortion diagnosed and treated in Hospital were selected in observation group, while 112 women with voluntary abortion were selected in control group from January to December 2020. The levels of miRNA-144, beta-human chorionic gonadotropin (β-hCG), estradiol (E2), progesterone (P) of the women were compared between the two groups, and the correlation between which and the hormone level of these women was analyzed. Results: The relative expression level of miRNA-144 (0.28±0.03) of the women in the observation group was significantly lower than that (1.22±0.22) of the women in the control group. The levels of the serum E2 (455.25±50.77 pg/ml),β- HCG (3618.91±23.58 mIU/ml), and P (7.43±3.31 ng/ml) of the women in the observation group were significantly lower than those (1477.29±50.12 pg/ml, 9755.87±63.45 mIU/ml, and 26.03±5.49 ng/ml) of the women in the control group (P=0.000). Through correlation analysis, the level of serum miRNA-144 of the women in the observation group were positively correlated with their levels of β- HCG, E2, and P (r=0.447, 0.521, 0.485，all P=0.000). Conclusion: The expression level of miRNA-144 the women with missed abortion decreases, which is significantly correlated with the level of their sex hormone. It is expected to be used as an important supplement for disease diagnosis and the pregnancy outcomes evaluation of the women with missed abortion.
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