|
|
|
| Effect of Xuefu zhuyu capsules combined with progesterone capsules for treating women after endometrial polyps surgery and its influence on the endometrial changes and recurrence of endometrial polyps and its mechanism |
| The Second People's Hospital of Fengrun District, Tangshan, Hebei Province, 064000 |
|
|
|
|
Abstract To investigate the influence of Xuefu zhuyu capsules combined with progesterone capsules for treating women after endometrial polyps(EP)surgery on their endometrial changes and the recurrence of their EP, and to study its molecular mechanism. Methods: A total of 78 women with EP who underwent hysteroscopic polypectomy were selected and were divided into group A(39 women with treatment of Xuefu zhuyu capsules combined with progesterone capsules for three menstrual cycle)and group B(39 women with treatment of progesterone capsules for three menstrual cycle)according to the random number table method from February 2018 to February 2021. The endometrial thickness, the menstrual blood loss chart(PBAC)score, the syndrome score, the levels of serum inflammatory factors, such as interleukin(IL)-4, IL-6, and tumor necrosis factor-α(TNF-α), and the expressions of progesterone receptor(PR), estrogen receptor(ER), and proliferating nuclear antigen-67(Ki-67)of the women before and after treatment were compared between the two groups. The curative effect and the rates of the adverse reactions and recurrence of PE in the 6th month and the 12th month after operation of the women in the two groups were counted. Results: After treatment, the endometrial thickness(0.61±0.19mm), PBAC score(56.74±9.17 points), and TCM syndrome score(7.68±1.95 points)of the women in group A were significantly lower than those(0.74±0.21mm, 64.25±12.08 points, and 10.32±2.27 points)of the women in group B. The levels of serum IL-4 and PR of the women in group A were significantly higher than those of the women in group B. The levels of serum IL-6, TNF-α, ER, and Ki-67 of the women in group A were significantly lower than those of the women in group B. The total effective rate(94.9%)of the women in group A was significantly higher than that(79.5%)of the women in group B(all P＜0.05). There were no significant differences in the incidences of adverse reactions(15.4% vs. 10.3%)and the recurrence of PE in the 6th month(0 vs. 2.7%)and the 12th month(8.1% vs.13.5%)between the two groups(P＞0.05). Conclusion: The application of Xuefu zhuyu capsules combined with progesterone capsules for treating the women after hysteroscopic endometrial polypectomy can reduce their endometrial thickness and the postoperative recurrence of PE, improve their clinical symptoms with safe and effectiveness. The mechanism may be related to reducing the inflammatory response and to regulating the PR, ER and Ki-67 expressions levels of the women.
|
|
|
|
|
|
|
|
|
