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| Value of pre-pregnancy basic sex hormone and anti-Mullerian hormone levels of advanced women of childbearing age for screening their ovarian reserve function |
| 1. Liangzhou Hospital, Wuwei, Gansu Province, 733000; 2. Gansu Provincial People's Hospital, Lanzhou; 3. Wuwei Municipal People's Hospital of Gansu Province |
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Abstract To investigate the values of the pre-pregnancy basal hormone and anti-mü llerian duct hormone levels of advanced women of childbearing age for screening their ovarian reserve function. Methods: A total of 498 advanced women of childbearing age who underwent pre-pregnancy examination were selected as the research subjects and were divided into group A (156 cases aged in <30 years old), group B (168 cases aged in 31-35 years old), and group C (174 cases aged in >35 years old) according to their age from April 2018 to April 2020. The levels of serum estradiol 2 (E2), follicle stimulating hormone (FSH), and luteinizing hormone (LH), anti-mullerian hormone (AMH) of the women in the three groups were detected. The value of the basic sex hormones levels combined with the AMH level of the women for screening their ovarian reserve function was analyzed by receiver operating characteristic curve. Results: The levels of serum FSH, E2, FSH/LH of the women in group A, group B, and group C had increased gradually, while the AMH level of the women in group A, group B, and group C had decreased gradually. The percentage of ovarian reserve function decreased of the women in group A, group B, and group C were 10.9%, 16.7%, and 25.3%, which had increased gradually (all P＜0.05). The area under the curve (AUC), the sensitivity, and the specificity of the basic sex hormones levels for screening ovarian reserve function of advanced women were 0.711, 71.2%, and 81.8%, respectively. The AUC, the sensitivity, and the specificity of the AMH level for screening ovarian reserve function of advanced women were 0.762, 74.3% and 87.4%, respectively. The AUC, the sensitivity, and the specificity of the basic sex hormones levels combined with the AMH level for screening ovarian reserve function of advanced women were 0.883, 84.2%, and 90.2%, respectively. Conclusion: The basic sex hormones levels combined with the AMH level of the advanced women for screening their ovarian reserve function can increase the detection value, which can be as the effective indicators for guiding the reproductive health care of the advanced women in clinic.
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