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| Analysis of pregnancy status and its related factors of patients with uterine fibroids after high intensity focused ultrasound treatment |
| Mianyang Hospital Affiliated to School of Medicine, University of Electronic Science and Technology, Mianyang, Sichuan Province, 621000 |
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Abstract To study the pregnancy status of patients with uterine fibroids after high intensity focused ultrasound (HIFU) treatment, and to analyze the related influencing factors of pregnancy of the patients after HIFU treatment. Methods: 124 patients with uterine fibroids were selected as the research subjects between February 2019 and December 2020. Among them, 21 cases with successful pregnancy after treatment were included in study group, and 103 cases without pregnancy were enrolled in control group. In the study group, 10 cases with successful delivery were in group A and 11 cases with spontaneous abortion were in group B. The general data of the patients were compared among these groups, and multivariate analysis was performed for analyzing the factors affecting the pregnancy of the patients. Results: The patients with pregnancy in the study group were all nature conceived successfully. The incidences of intraoperative skin burn and postoperative recurrence of uterine fibroids of the patients in the study group were significantly lower than those of the patients in the control group. There were significant differences in the incidence of pregnancy history, the fibroid size, the postoperative symptom improvement situation, and the proportion of fibroid volume reduction ≥70% in the 3rd month after surgery of the patients between the two groups (all P＜0.05). There were no significant differences in the age, the number of fibroids, the type of fibroids, and the fibroid location of the patients between the two groups (P＞0.05). There were no significant differences in the pregnancy and delivery history, the fibroid number, the fibroid type, the fibroid location, and the postoperative symptom improvement situation of the patients between group A and group B (P＞0.05), but there were significant differences in the age and the proportion of fibroid volume reduction ≥70% in the 3rd month after surgery of the patients between group A and group B (P＜0.05). The postoperative recurrence of fibroid (OR=1.765), the postoperative symptom improvement (OR=2.664), and the fibroid volume reduction ≥70% in the 3rd month after surgery (OR=3.124) of the patients were the influencing factors of their successful pregnancy (P＜0.05), and the age (OR=2.342) and the fibroid volume reduction ≥70% in the 3rd month after surgery of the patients were the influencing factors of their successful delivery (P＜0.05). Conclusion: After HIFU treatment, some of the patients with uterine fibroids can successfully conceive and give birth. The postoperative recurrence of fibroid, the postoperative symptom improvement, and the fibroid volume reduction ≥70% in the 3rd month after surgery of the patients are the main factors influencing their postoperative pregnancy. The age and the fibroid volume reduction ≥70% in the 3rd month after surgery of the patients are the main factors influencing their delivery after pregnancy.
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