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| Effect of tranexamic acid combined with cabletide for prevention of pastpartum hemorrhage women with dangerous placenta previa after cesarean section and its influence on uterine arterial blood flow dynamics and maternal and infant outcomes |
| Gansu Maternal and Child Health Care Hospital， Lanzhou，Gansu Province, 730050 |
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Abstract To study the effect of tranexamic acid combined with cabletide for treating women with dangerous placenta previa after cesarean section, and to explore its influence on their uterine arterial blood flow dynamics and maternal and infant outcomes. Methods: 200 pregnant women with dangerous placenta previa were selected and divided into experimental group (n=105) and control group (n=95) by random number table method from January 2018 to January 2022. The women in the control group were treated by capitin, and the women in the experimental group were treated by capitin combined with tranexamic acid. The efficacy, the values of hemodynamics of uterine artery, the intraoperative and postoperative blood loss, the postoperative blood transfusion, the maternal and infant outcomes, and the incidence of adverse reactions of the women were compared between the two groups. Results: The total effective rate (98.1%) of the women in the experimental group after treatment was significantly higher than that (81.1%) of the women in the control group. The values of uterine artery blood flow pulsatile index (PI) and resistance index (RI) of the women in the two groups after treatment were significantly higher than those before treatment, and the amplitudes of which of the women in the experimental group were significantly greater than those of the women in the control group. The intraoperative blood loss (1118.5±49.6 ml), the postoperative blood loss (82.6±25.9 ml), and the intraoperative blood transfusion volume (438.3±43.8 ml) of the women in the experimental group were significantly lower than those (1161.4±58.3 ml, 329.0±36.5 ml, and 1025.6±36.8 ml) of the women in the control group (all P＜0.05). There was no significant difference in the incidence of neonatal death (0 vs. 2.1%) between the two groups (P＞0.05). The incidences of neonatal asphyxia (1.0%), premature birth (2.9%), and hysterectomy (0) of the women in the experimental group were significantly lower than those (7.4%, 11.6%, and 4.2%) of the women in the control group (all P＜0.05). There was no significant difference in the total incidence of adverse reactions (6.7% vs. 9.5%) between the two groups (P＞0.05). Conclusion: Tranexamic acid combined with cabletide for treating women with dangerous placenta previa after cesarean section has high effect, which can improve their hemodynamics of uterine artery and their maternal and infant outcomes.
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| Cite this article: |
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MA Xiaoli. Effect of tranexamic acid combined with cabletide for prevention of pastpartum hemorrhage women with dangerous placenta previa after cesarean section and its influence on uterine arterial blood flow dynamics and maternal and infant outcomes[J]. 中国计划生育学杂志, 2022, 30(10): 2272-.
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| URL: |
| https://www.zgjhsyx.com/EN/ OR https://www.zgjhsyx.com/EN/Y2022/V30/I10/2272 |
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