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Abstract To explore the influence of laparoscopic cystectomy for treating women with unilateral ovarian endometriotic cysts (OEC) on their arterial hemodynamics and their serum perredoxin (PRX) subtypes expression. Methods: The clinical data of 122 women with unilateral OEC in observation group and 45 healthy women in control group from February 2017 to March 2020 were analyzed retrospectively. The women in the observation group had received laparoscopic cystectomy. The total effective rate, the operative time, the intraoperative blood loss, the hospitalization time, the recurrence rate, the values of uterine artery hemodynamics, such as RI, PI, and S/D, and the levels of serum perredoxin subtypes, such as PRX1, PRX2, and PRX3 before and in 7 days after operation, and the ovarian function-related indicators of the women in the observation group were observed. According to the OEC recurrence after operation, the women in the observation group were divided into group A 28 women with OEC recurrence) and group B (94 women without OEC recurrence). The relevant factors affecting OEC recurrence of the women in the observation group after operation were analyzed. The values of RI, PI, and S/D, and the levels of PRX1, PRX2, and PRX3 for predicting postoperative OEC recurrence of the women were assessed by receiver operator characteristic curve (ROC). Results: The total effective rate after treatment, the operation time, the intraoperative blood loss, the hospital stay, and the OEC recurrence rate after 12 months of follow-up of the women in the observation group were 93.4%, 82.2±12.3min, 54.3±5.3ml, 4.1±1.3 days, and 23.0%, respectively. The preoperative hemodynamic indexes values of the women in the observation group were significantly higher than those of the women in the control group, while the expressions levels of PRX1, PRX2, and PRX3 of the women in the observation group were significantly lower. After treatment, the hemodynamic indexes values of the women in the observation group had decreased significantly, while the expressions levels of PRX1, PRX2, and PRX3 of the women in the observation group had increased significantly (all P＜0.05). The levels estradiol (E2), follicle stimulating hormone (FSH), and luteinizing hormone (LH) of the women in the observation group had no changed after treatment, and which had no significantly different from those of the women in the in the control group (P＞0.05). There were no significant differences in the body mass index value, the age of menarche, the number of induced abortion, the levels of E2, FSH, and LH, and the maximum cyst significant diameter of the women between group A and group B (P＞0.05), but there were significant differences in the age, the OEC duration, the OEC r-AFS stage, the number of postoperative pregnancy, the values of RI, PI, and S/D, and the PRX1, PRX2, and PRX3 levels of the women between group A and group B (P＜0.05). Binary logistic regression analysis showed that OEC r-AFS stage Ⅲ-Ⅳ, the no postoperative pregnancy, the younger age, the longer disease course, the abnormal RI, PI, and SD values, and the abnormal expressions of PRX1, PRX2, and PRX3 of the women with OEC were the risk factors of their postoperative OEC recurrence (P＜0.05). ROC analysis showed that the AUC of the values of RI, PI, and SD, and the levels of PRX1, PRX2, and PRX3 of the women with OEC for predicting their recurrence after OEC were 0.580, 0.661, 0.826, 0.680, 0.754, and 0.752, respectively (P＜0.05). Conclusion: Laparoscopic cystectomy for treating women with OEC has high effect, which is beneficial to reduce the recurrence rate of OEC. The arterial hemodynamics and the PRX subtype detection of the women with OEC can be used as the reference indicators for predicting the postoperative OEC recurrence of these women.
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