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Abstract To explore the clinical effect of Zishen antai decoction combined with chorionic gonadotropin (HCG) and progesterone for treating women with threatened abortion. Methods: 104 women with threatened abortion who wanted diagnosis and treatment were selected and were divided into two groups according to random lottery from July 2018 to October 2020. 52 women in the control group were treated with HCG combined with progesterone for 2 weeks, and 52 women in the observation group were treated with Zishen antai decoction combined with HCG and progesterone for 2 weeks. The clinical efficacy of the women in the two groups was evaluated. The TCM syndrome scores, such as lower abdominal pain, the vaginal bleeding volume, the backache rate, and the knees sore, of the women before and in 2 weeks after treatment, the levels of endocrine hormone, such as β-human chorionic gonadotropin (β-hCG), Progesterone (P), and estradiol (E2), the levels of Th1/Th2 cytokines, such as γ interferon (IFN-γ), interleukin 2 (IL-2), and interleukin 4 (IL-4), and the value changes of immune indicators, such as T lymphocyte subsets (CD4+, CD8+ and CD4+/CD8+) of the women in the two groups were analyzed. Results: After 2 weeks of treatment, the total effective rate (94.2%) of the women in the observation group was significantly higher than that (80.8%) of the women in the control group. The score of lower abdominal pain, the vaginal bleeding volume, the backache rate, and the knees sore rate of the women in the observation group were significantly lower than those of the women in the control group (P＜0.05). The levels of β-hCG, P, and E2 of the women in the two groups had increased significantly, and which of the women in the observation group were significantly higher than those of the women in the control group. The levels of INF-γ and IL-2 of the women in the two groups had decreased significantly, and the level of IL-4 had increased significantly, and the changes of which of the women in the observation group were significantly more than those of the women in the in control group. The changes of CD4+ and CD8+ levels of the women in the observation group were significantly more than those of the women in the control group. The value of CD4+/CD8+ of the women in the two groups had decreased significantly, and the variations of which of the women in the observation group were significantly more than those of the women in the control group (P＜0.05). Conclusion: Zishen antai decoction combined with chorionic gonadotropin and progesterone for treating women with threatened abortion can reduce their symptoms, increase their endocrine hormones levels and their immune function, and improve their clinical efficacy.
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