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Abstract To investigate the expressions of serum vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), monocyte chemoattractant protein 1 (MCP-1), and metalloproteinase-9 (MMP-9)/matrix metalloproteinase inhibitor-1 (TIMP-1) of women with endometriosis (EMs), and to study their clinical significance. Methods: A total of 124 women with EMs were selected in study group and 124 women who received healthy physical examinations were selected in control group from January 2020 to December 2021. The levels of serum VEGF, IGF-Ⅰ, MCP-1, and MMP-9/TIMP-1 of the women were compared between the two groups, among the women with different stage of EMs, and between the women with and without infertile. And the correlation of the levels of serum VEGF, IGF-Ⅰ, MCP-1, and MMP-9/TIMP-1 of the women was analyzed. Results: The levels of serum VEGF (252.45±51.49 ng/L), IGF-Ⅰ(142.89±30.11 ng/ml), MCP-1 (30.74±4.21 ng/ml), and MMP-9/TIMP-1 (2.07±0.32) of the women in the study group were significantly higher than those (143.32±31.18 ng/L, 52.23±16.44 ng/ml, 8.44±1.45 ng/ml, and 0.55±0.14) of the women in the control group, and which of the women in the study group had increased with the increase of r-AFS stage of EMs of the women. The levels of VEGF, IGF-Ⅰ, MCP-1, and MMP-9/TIMP-1 of the women with infertility in the study group were significantly higher than those of the women without infertility (all P＜0.05). Correlation analysis showed that the levels of serum VEGF, IGF-Ⅰ, MCP-1, and MMP-9/TIMP-1 of the women were positively correlation with their r-AFS stage of EMs, and the VEGF level, IGF-Ⅰlevel, MCP-1 level, and MMP-9/TIMP-1 of the women with Ems had positive correlation each other (P＜0.05). Conclusion: The expression levels of serum VEGF,IGF-Ⅰ,MCP-1, and MMP-9/TIMP-1 of the women with EMs are abnormal high, and which are related to the severity of EMs and the infertility of the women.
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