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| Correlation between the levels of serum interleukin-6, interleukin-10, and tumor necrosis factor-αof premature infants with intrauterine infection and their myocardial enzyme indexes levels and brain injury |
| 1. The Eighth People's Hospital of Hefei, Hefei, Anhui Province, 238000；2. Chaohu Hospital of Anhui Medical University |
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Abstract To explore the correlation between the levels of serum interleukin (IL) -6, IL-10, and tumor necrosis factor-α(TNF-α) of premature infants with intrauterine infection and their myocardial enzyme indexes levels and brain injury. Methods: The clinical data of 160 preterm infants from January 2017 to May 2021 were analyzed retrospectively. Among them, 77 infants with intrauterine infection were included in group A, and 83 infants without intrauterine infection were included in group B. In the group A, there were 41 cases with brain injury and 36 cases without brain injury. The levels of serum IL-6, IL-10, and TNF-α, and the levels of myocardial enzymes indexes of the infants in the two groups were detected. The correlation between the levels of serum IL-6, IL-10, and TNF-αof the infants and their levels of creatine kinase (CK), α-hydroxybutyrate dehydrogenase (α-HBDH), and their brain injury was analyzed. Results: The levels of serum IL-6 and TNF-α, and the levels of CK and α-HBDH of the infants in group A were significantly higher than those of the infants in group B, but the level of IL-10 of the infants in group A was significantly lower. In group A, the levels of serum IL-6 and TNF-α of the infants with brain injury were significantly higher than those of the infants without brain injury, but the level of IL-10 of the infants with brain injury was significantly lower (all P<0.01). Person correlation analysis showed that the CK level of the infants was positively correlated with their IL-6 and TNF-α levels, but was negatively correlated with their IL-10 level. The level of α-HBDH of the infants was positively correlated with their IL-6 and TNF-αlevels, but was negatively correlated with their IL-10 level (all P<0.05). Conclusion: There were some correlation between the levels of serum IL- 6, IL-10, and TNF-αof the premature infants with intrauterine infection and their myocardial enzyme indexes levels and brain injury. So in clinical practice, the serum IL-6, IL-10, and TNF-αlevels of these infants should be monitor strengthen, so as to provide the references for evaluating the neonatal brain injury and myocardial enzyme levels.
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