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| Expressions and clinical significance of Toll-like receptor 4 and NOD-like receptor protein 3 inflammasomes in peripheral blood of women with unexplained recurrent spontaneous abortion |
| Bayannaoer City Hospital, Bayannaoer, Inner Mongolia, 015000 |
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Abstract To explore the expressions and clinical significance of Toll-like receptor 4 (TLR4) and NOD-like receptor protein 3 (NLRP3) inflammasomes in peripheral blood of women with unexplained recurrent spontaneous abortion (URSA). Methods: 65 women with URSA were enrolled in observation group and 30 women with normal early pregnancy who wanted induced abortion were selected in control group between June 2019 and June 2021. The general data, the levels of β-human chorionic gonadotropin (β-hCG) and progesterone (P), and the expressions of TLR4 and NLRP3 inflammasomes in peripheral blood of the women were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between the expressions of TLR4 and NLRP3 inflammasomes in peripheral blood of the women in the observation group and their levels of β-hCG and P. Logistics regression equation was used to analyze the correlation between the expressions of peripheral blood TLR4 and NLRP3 inflammasomes of the women in the observation group and their URSA. Results: The levels of serum β-HCG and P of the women in the observation group were significantly lower than those of the women in the control group, and the expressions of TLR4 mRNA, NLRP3 mRNA, ASC mRNA, and caspase-1 mRNA in peripheral blood of the women in the observation group were significantly higher than those of the women in the control group (all P<0.05). The expressions of TLR4 mRNA, NLRP3 mRNA, ASC mRNA, and caspase-1 mRNA in peripheral blood of the women in the observation group were correlated with theirβ-HCG and P levels (P<0.05). Logistic regression analysis showed that the expressions of TLR4 mRNA, NLRP3 mRNA, ASC mRNA, and caspase-1 mRNA in peripheral blood of the pregnant women were the related factors of their URSA (P<0.05). Conclusion: The expressions of TLR4 mRNA, NLRP3 mRNA, ASC mRNA, and caspase-1 mRNA in peripheral blood of the women with URSA increase abnormally. The immune inflammatory response may be involved in the process of URSA of the women.
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