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| Research progress of mesenchymal stem cells from different sources in the treatment of premature ovarian insufficiency |
| 1.Guangdong Medical University，Zhanjiang, Guangdong Province, 524023; 2.Reproductive Center of Affiliated Hospital of Guangdong Medical University |
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Abstract Premature ovarian insufficiency (POI）refers to the decline or loss of ovarian function of the women before 40 years old, which seriously affects the physical and mental health, and the reproductive function of these women. With the liberalization of the national three child policy, the adverse impact of POI on the fertility of the women is becoming more and more serious. Early detection, early treatment and iatrogenic intervention for the women with POI are particularly important to slow down their ovarian decline. Mesenchymal stem cells (MSCs）have the characteristics of differentiating into osteoblasts, chondrocytes, and adipocytes. More and more studies have confirmed that MSCs from different tissue sources are preferentially implanted into damaged tissues, which can show strong regeneration, differentiation, and repair ability. At present, MSCs have been used to repair ovarian failure caused by chemotherapy, but there are still many unknown mysteries about MSCs. Based on the previous research results, this paper summarizes the latest research progress of MSCs from different sources to improve the ovarian function of the women with POI through diversified biochemical pathways and gene expression pathways, so as to strive the application of the means of MSCs for treating POI in clinic as soon as possible, to benefit the majority of the women with POI, and to provide the evidences for translational medicine. At the same time, it provides more novel ideas for reproductive doctors to treat POI.
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