|
|
|
| The changes of serum 25-hydroxyvitamin D and pre-S1 antigen levels of pregnant patients with hepatitis B virus infection and their correlation with the prognosis of the perinatal infants |
| The Third People's Hospital of Anyang City, Anyang, Henan Province, 455000 |
|
|
|
|
Abstract To explore the changes of serum 25-hydroxyvitamin D ［(OH)D］ and pre-S1 antigen (PreS1Ag) levels of pregnant women with hepatitis B virus (HBV) infection, and to study their correlation with the prognosis of the perinatal infants. Methods: A total of 109 pregnant women with HBV infection were selected and were divided into 41 women with infection symptom in group A and asymptomatic 68 women in group B from August 2018 to June 2020. Another 62 normal pregnant women were enrolled group C during the same period. The levels of serum 25-(OH) D and PreS1Ag of the women were compared among the three groups. The correlation between the serum 25-(OH) D and PreS1Ag levels of the women and their perinatal infants was analyzed. Results: The serum 25-(OH) D level of the women in group A (20.17±1.09 ng/ml) was significantly lower than that of the women in group B or group C, and the positive rate of PreS1Ag of the women in group A (75.6%) was significantly higher than that of the women in group B or group C. The incidences of the pregnancy complications and the adverse pregnancy outcomes of the women in group A were significantly higher than those of the women in group B or group C (all P<0.05). There were no significant differences in the incidences of the pregnancy complications and the adverse pregnancy outcomes of the women between group B and group C (P>0.05). The range of the serum 25-(OH)D levels of the women with PreS1Ag positive were mainly in the two intervals of 10-19 ng/mL and 20-29 ng/ml. The incidence of perinatal adverse prognosis (46.3%) of the women with PreS1Ag positive was significantly higher than that (11.9%) of the women with PreS1Ag negative (P<0.05). The serum 25-(OH) D level of the women in group A was correlated with their PreS1Ag positive rate and their perinatal adverse prognosis (P<0.05). Conclusion: The abnormal changes of serum 25-(OH) D and PreS1Ag levels of the pregnant women with HBV infection will affect the prognosis of their perinatal infants. The incidence of adverse prognosis of perinatal infants of the women with PreS1Ag positive or with low serum 25-(OH) D level is higher, which indicates that early intervention and treatment for those women with PreS1Ag positive or with low serum 25-(OH)D level can improve the prognosis of their perinatal infants in clinic.
|
|
|
|
|
|
|
|
|
