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| Expression of serum interferon γ-induced protein 16 of pregnant women with preeclampsia and its correlation with their uterine artery blood flow parameters |
| The Second Affiliatecl Hospital Zhejiang University School of Medicine, Linping Campus, Zhejiang Province, 310003 |
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Abstract To analyze the correlation between the level of serum interferon γ -induced protein 16 (IFI16) of pregnant women with preeclampsia (PE) and their uterine artery blood flow parameters. Methods: From January 2019 to December 2020, 116 pregnant women with PE from Linping branch of the second affiliated hospital of medical college of Zhejiang university were selected in study group, which included 81 women with mild PE in group A and 35 women with severe PE in group B. 90 healthy pregnant women were selected in control group. The systolic peak/end-diastolic flow rate（S/D), the resistance index（RI), and the pulse index（PI) of uterine artery blood flow parameters of these women were detected by ultrasound. And the serum IFI16 level of these women was detected. Results: The levels of serum IFI, S/D, RI, and PI of the women in the study group were significantly higher than those of the women in the control group, and which of the women in group B were significantly higher than those of the women in group A (all P<0.001). The uterine artery RI value of the pregnant women with IFI≥11.4ng/mL in group A was significantly higher than that of the pregnant women with IFI <11.4ng/mL, and the uterine artery S/D, , and PI values of the pregnant women with IFI≥16.2ng/ml in group B were significantly higher than that of the pregnant women with IFI <16.2ng/ml (all P<0.05). The serum IFI16 level of the women in group A was positively correlated with their uterine artery PI value (P<0.05), but was no correlation with their S/D and PI values (P>0.05). The serum IFI16 level of the women in group B was positively correlated with their S/D, PI, and RI values of uterine artery (P<0.05). Conclusion: IFI16 of the pregnant women is involved in the development of their PE, and which has correlation with their uterine artery blood flow parameters.
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