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| Correction between the serum folate and VB12 levels of pregnant women with gestational hypertension and their adverse pregnancy outcomes |
| Daxing District People's Hospital of Beijing, Beijing, 10260 |
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Abstract To investigate the levels of serum folic acid and vitamin B12（VB12）of pregnant women with gestational hypertension and their adverse pregnancy outcomes. Methods：The clinical data of 188 pregnant women with gestational hypertension and delivery from March 2020 to September 2020 were collected. According to the pregnancy outcomes，these women were divided into group A (76 cases with adverse pregnancy outcomes) and group B (112 cases with normal pregnancy outcomes). The clinical data of these women were collected. Enzyme-linked immunoassay was performed to measure the expression levels of serum folic acid and VB12 of these women. Pearson method was used to analyze the correlation between the serum folic acid level and the serum VB12 level. Receiver operating characteristic（ROC）curve was performed to evaluate the diagnostic value of serum folate and VB12 levels for adverse pregnancy outcomes. The factors influencing the adverse pregnancy outcomes of the women were analyzed. Results：The levels of serum folic acid (17.98±3.85 nmol/L) and VB12 (210.21±61.89ρmol/L) of the women in group A were significantly lower than those (21.31±4.56 nmol/L and 278.56±79.54ρmol/L) of the women in group B. The values of systolic blood pressure, diastolic blood pressure, and 24h urinary protein of the women in group A were significantly higher than those of the women in group B. The gestational weeks and the gestational weeks of gestational hypertension onset of the women in group A were significantly lower than those of the women in group B (all P<0.05). The serum folic acid level of the women with gestational hypertension was positive correlation with their serum VB12 level (r=0.296, P<0.05). ROC curve showed that the area under the curve (AUC) of the serum folic acid level and the VB12 level of the women with gestational hypertension for predicting their adverse pregnancy outcomes were 0.751 (95%CI：0.683-0.811) and 0.748 (95%CI：0.679-0.808), the sensitivity of which were 79.2% and 77.2%, and the specificity of which were 65.5% and 67.8%. The AUC of the combined serum folic acid and VB12 levels for predicting adverse pregnancy outcomes was 0.834 (95%CI: 0.773-0.884), the sensitivity and the specificity of which were 79.2% and 72.4%. Logistic regression analysis showed that the abnormal levels of folic acid and VB12, the abnormal 24h urinary protein value, and the increased diastolic and systolic blood pressure values of the women with gestational hypertension were their risk factors of adverse pregnancy outcomes. Conclusion：The expressions of serum folic acid and VB12 of the pregnant women with gestational hypertension decrease, and there are positively correlation between the folic acid level and the VB12 level, which suggest that the serum folic acid and VB12 levels can be used to predict their adverse pregnancy outcomes of the pregnant women with gestational hypertension.
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