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| The effect of ropivacaine combined with sufentanil for postoperative analgesia after radical resection of cervical cancer, and its influence on the immune function and tumor markers levels |
| 1.Marine Police Corps Hospital, Jiaxing, Zhejiang Province, 314001; 2. Jiaxing Maternal and Child Health Care Hospital, Zhejiang Province |
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Abstract To investigate the effect of ropivacaine combined with sufentanil for postoperative analgesia of patients after radical resection of cervical cancer, and to study its influence on the immune function and tumor markers levels of the patients. Methods: 126 patients who underwent elective radical resection of cervical cancer were selected and were divided into two groups according the random number table from June 2019 to June 2021. 64 patients in the control group were given sufentanil targeted infusion, and 64 patients in the observation group were given ropivacaine combined with sufentanil intercostal nerve block anesthesia after induction of general anesthesia. The visual analogue scale (VAS) scores, the Ramsay sedation scores, the stress response, the immune function, and the changes of serum tumor markers levels of the patients after operation were compared between the two groups. Results: The number of self-controlled analgesia pump press (1.69±0.42 times) and the dose of sufentanil used (49.20±8.12μg) of the patients in the observation group were significantly lower than those (4.28±0.56 times and 71.68±9.63μg) of the patients in the control group (all P<0.05). There were no significant differences in the VAS score and the Ramsay sedation score of the patients in postoperative 1 h between the two groups (P>0.05). The VAS scores of the patients the observation group in postoperative 6h, 12h, and 24h were significantly lower than those of the patients in the control group, the Ramsay sedation scores of the patients in the observation group in postoperative 12h and 24h were significantly higher than those of the patients in the control group (all P<0.05). The levels of serum catecholamine, epinephrine, cortisol, carcinoembryonic antigen, carbohydrate antigen 125, squamous cell carcinoma associated antigen of the patients the observation group in postoperative 24h were significantly lower than those of the patients in the control group, and the levels of CD3+, CD4+, CD4+/CD8+, and NK cells of the patients the observation group in postoperative 24h were significantly higher than those of the patients in the control group (all P<0.05). Conclusion: Ropivacaine combined with sufentanil intercostal nerve block anesthesia during radical resection of cervical cancer can effectively reduce their postoperative pain and their stress response, improve their immune function and decrease their serum tumor markers levels.
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