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| Effects of sevoflurane inhalation combined anesthesia guided by bispectral index during laparoscopic radical resection of cervical cancer of patients on their cognitive function and the levels of serum cortisol and angiotensin II |
| 1.Nanchong Central Hospital, Nanchong, Sichuan Province, 637000; 2.Guang'an People's Hospital |
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Abstract To explore the effects of sevoflurane inhalation combined anesthesia guided by bispectral index (BIS) during laparoscopic radical resection of cervical cancer of patients on their cognitive function and their serum cortisol (Cor) and angiotensin II (Ang-II) levels. Methods: A total of 106 patients who wanted laparoscopic radical resection of cervical cancer were enrolled and were randomly divided into two groups (53 cases in each group) between January 2018 and March 2021. The patients in the two groups were all given sevoflurane inhalation combined with propofol for anesthetics. The patients in the control group were given the anesthetics according to clinical experience of anesthesiologists, while the patients in the observation group were given the anesthetics guided by BIS. The dosages of anesthetics, the values of blood pressure indexes, such as systolic blood pressure (SBP), diastolic blood pressure (DPB), the heart rate (HR), the values of serum indexes, such as Cor and Ang-II, the recovery quality score, and the score of cognitive function MMSE of the patients were compared between the two groups. Results: There was no significant difference in the dosage of sevoflurane of the patients between the two groups (P>0.05), and the dosage of propofol of the patients in the observation group was significantly lower than that of the patients in the control group (P<0.05). The HR value of the patients in the observation group at 10min or 30min after pneumoperitoneum, or at the end of the operation was significantly lower than that of the patients in the control group, but the values of SBP and DPB of the patients in the observation group were significantly higher than those of the patients in the control group. The levels of Cor and Ang-Ⅱof the patients in the observation group at the end of the operation or at postoperative 2h were significantly lower than those of the patients in the control group, and the postoperative consciousness recovery time, the spontaneous breathing recovery time, and the awake time of the patients in the observation group were significantly shorter than those of the patients in the control group (all P<0.05). There was no significant difference in the cognitive function of the patients at 7 days before and after operation between the two groups (P>0.05). MMSE score of cognitive function of the patients in the observation group in the 1st d, the 3rd d, or the 5th d after operation was significantly higher than that of the patients in the control group (P<0.05). Conclusion: Sevoflurane inhalation combined anesthesia guided by BIS during laparoscopic radical resection of cervical cancer of the patients can reduce their dosages of related anesthetics used, can decrease their stress response, and can fast the recovery of their postoperative cognitive function, which is also of positive significance in avoiding awakening delay.
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