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| Influencing factors of abnormal postpartum blood glucose of women with gestational diabetes mellitus and the predictive value of the levels of glycosylated hemoglobin combined with fasting plasma glucose for abnormal postpartum blood glucose |
| 1.The First People's Hospital of Guangyuan, Sichuan Province 628000; 2. Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province |
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Abstract To explore the influencing factors of abnormal postpartum blood glucose of women with gestational diabetes mellitus (GDM), and to study the predictive value of the levels of glycosylated hemoglobin (HbA1c) combined with fasting plasma glucose (FPG) for abnormal postpartum blood glucose. Methods: A total of 131 singleton pregnant women with GDM were selected as the research subjects from June 2019 to June 2020. These women were divided into study group (39 women with abnormal postpartum blood glucose) and control group (92 women with normal postpartum blood glucose). The general data of the women in the two groups were collected and their blood glucose levels were detected. The risk factors of abnormal postpartum blood glucose of the women with GDM were analyzed by multivariate Logistic regression analysis. The diagnostic value of the levels of HbA1c combined with FPG in different pregnant stage for abnormal postpartum blood glucose level was analyzed. Results: Logistic regression analysis showed that age ≥28 years old, the family history of diabetes, the level of FPG ≥5.59mmol/L during pregnancy, and the HbA1c level ≥5.45% duration pregnancy, the time of postpartum exercise training ≤1h/d of the women with GDM were the independent risk factors of their postpartum glucose abnormalities (P<0.05). The levels of HbA1c and FPG of the women in the study group during the first, the second, or the third trimester of pregnancy were significantly higher than those of the women in the control group (P<0.05). The area under the receiver operator characteristic curve of the levels of HbA1c combined with FPG for diagnosing abnormal postpartum blood glucose of the women with GDM during different pregnant stage were all >0.9, and the specificity and the sensitivity of the levels of HbA1c combined with FPG during the second and the third trimester of pregnancy for diagnosing abnormal postpartum blood glucose were >90%. Conclusion: The levels of HbA1c and FPG of the women with abnormal postpartum glucose level during the first, the second, and the third trimester of pregnancy are all significantly higher than those of the women without abnormal postpartum glucose level, and both of the levels of HbA1c and FPG have high values for predicting the abnormal postpartum glucose level of the women. The age ≥28 years old, the family history of diabetes, the level of FPG ≥5.59mmol/L during pregnancy, and the HbA1c level ≥5.45% duration pregnancy, and the time of postpartum exercise training ≤1h/d of the women with GDM are related to their abnormal postpartum glucose level, which suggests early prediction and timely intervention should be conducted in clinic.
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