To explore effects of letrozole combined with triprireline for treating patients with polycystic ovarian syndrome (PCOS) complicated with ovulation disorders on their clinical pregnancy rate and serum sex hormone binding globulin (SHBG) and insulin-like growth factor-1 (IGF-1) levels. Methods: A total of 116 patients with PCOS complicated with ovulation disorder were selected and were divided into control group and observation group (58 patients in each group) according to random number table method from January 2019 to March 2021. The patients in the control group were treated with letrozole, and the patients in the observation group were treated with letrozole combined with tripreline. The ovulation effect on the day of ovulation induced, the pregnancy outcomes, and the levels of sex hormone, SHBG, and IGF-1 of the patients were compared between the two groups. Results: After treatment, the endometrial thickness and the number of mature follicles of the patients in the observation group were significantly higher than those of the patients in the control group. The ovulation rate (96.6%), the pregnancy rate (37.9%), the rate of ovarian cyst occurrence (1.7%), and the incidence of follicular hyperstimulation syndrome (0) of the patients in the observation group were significantly lower than those (72.4%, 20.7%, 13.8%, and 8.6%) of the patients in the control group. The levels of E2 of the patients in the observation group were significantly lower than those of the patients in the control group. The SHBG level (159.46±65.74 mmol/L) of the patients in the observation group was significantly higher than that (139.54±62.46 mmol/L) of the patients in the control group, but the IGF-1 level (270.78± 41.39μg/L) of the patients in the observation group was significantly lower than that (321.32± 62.95μg/L) of the patients in the control group (P<0.05). Conclusion: Letrozole combined with tripraline for treating the patients with PCOS complicated with ovulation disorders can increase their levels of sex hormone, SHBG, and IGF-1, and also can improve their clinical pregnancy rate.