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| Diagnostic value of prenatal three-dimensional ultrasound, magnetic resonance imaging, and serum AFP level for fetal spina bifida |
| 1.Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu Province, 215101；2.The First Affiliated Hospital of Soochow University, Suzhou |
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Abstract To explore the diagnostic value of prenatal three-dimensional ultrasound, magnetic resonance imaging (MRI), and serum alpha-fetoprotein (AFP) level for fetal spina bifida. Methods: Retrospective analysis was conducted on 135 pregnant women with suspected fetal spina bifida from March 2016 to March 2021. The serum AFP level of these women was detected, and the examinations of MRI and three-dimensional ultrasound of these women were also performed, and which diagnostic accuracy rate was compared. Receiver operating characteristic (ROC) curve was used to predict the diagnostic efficacy of the serum AFP level, and the results of MRI and three-dimensional ultrasound examinations for fetal spina bifida. Results: 114 fetuses with spina bifida were confirmed by induced labor or delivery in 135 women with suspected fetal spina bifida. The diagnostic accuracy rate of the serum AFP level, and the result of MRI or threedimensional ultrasound, and the combined of the serum AFP level and the results of MRI and three-dimensional ultrasound for fetal spina bifida were 76.3%, 88.2%, 83.0%, and 98.5%, respectively. ROC curve analysis showed that the AUC of the serum AFP level, and the result of MRI or three-dimensional ultrasound, and the combined of the serum AFP level and the results of MRI and three-dimensional ultrasound for predicting fetal spina bifida were 0.872, 0.724, and 0.972, respectively. Conclusion: The combination of the serum AFP level and the results of MRI and three-dimensional ultrasound for fetal spina bifida can improve the accuracy of diagnosis.
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