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| Correlation between the insulin-like growth factor I, interleukin-18, and tumor necrosis factor-αlevels of pregnant women and their subclinical hypothyroidism occurrence |
| The Second People's Hospital of Huaian City, Jiangsu Province, 223002 |
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Abstract To investigate the correlation between the insulin-like growth factor I (IGF-I), interleukin-18 (IL-18), and tumor necrosis factor-α(TNF-α) levels of pregnant women and their subclinical hypothyroidism (SCH) occurrence. Methods: 123 pregnant women with SCH were selected in study group and 153 healthy pregnant women were selected in control group between January 2019 and December 2020. The levels of serum IGF-1, IL-18, and TNF-α of the women were compared between the two groups. Results: The level of thyroid stimulating hormone (TSH) of the women in the study group was significantly higher than that of the women in the control group. During the first, the second, and the third trimester of pregnancy, the IGF-1 level of the women in the study group was significantly lower than that of the women in the control group, while the levels of IL-18 and TNF-α of the women in the study group were significantly higher than those of the women in the control group (all P＜0.01). The IGF-1 level of the women was negatively correlated with their SCH occurrence, while the levels of IL-18 and TNF-α of the women were positively correlated with their SCH occurrence. Multiple linear regression analysis showed that during the first trimester of pregnancy, the IGF1 level of the women was negatively correlated with their TSH level (Beta=-0.463, P=0.003), while the IL-18 level (Beta=-0.144, P=0.007) and the TNF-α level (Beta=0.133, P=0.009) of the women were positively correlated with their TSH level. Conclusions: The levels of IGF-1, IL-18, and TNF-α of the pregnant women are all correlate with their TSH level, which maybe as the detection indexes of SCH in clinic.
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