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| Values of serum HK10 and PIVKA -Ⅱ levels for diagnosing and predicting the prognosis of ovarian cancer |
| Guangdong Maternal and Child Health Care Hospital, Guangzhou, Guangdong Province, 511000 |
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Abstract To study the value of serum HK10 and PIVKA --Ⅱ levels for diagnosing and predicting the prognosis of ovarian cancer of patients. Methods: In this prospective study, 156 patients with ovarian cancer were selected in study group from January 2013-January 2018. During 3 years followed up after treatment, 101 patients in the study group who survived were included in group A, and other 55 patients who died were included in group B. 156 volunteers who underwent physical examination during the same period were selected in control group. The levels of serum HK10 and PIVKA-Ⅱ of the patients were compared between the study group and the control group, and between group A and group B. The serum HK10 and PIVKA-Ⅱ levels for diagnosing and predicting the prognosis of ovarian cancer of the patients were analyzed. Results: The levels of HK10 (2.74±1.37 mg/L) and PIVKA-Ⅱ(35.21±1.95 U/L) of the patients in the study group were significantly higher than those (0.70±0.51 mg/L and 18.60±1.96 U/L) of the patients in the control group. The levels of HK10 (2.10± 0.77mg /L) and PIVKA-Ⅱ (33.76±1.17U /L) of the patients in group A were significantly lower than those (3.92±1.98mg /L and 37.87±1.01U /L) of the patients in group B (all P=0.000). The area under of the curve of the levels of HK10 combined with PIVKA-Ⅱ for diagnosing ovarian cancer was 0.950, and the critical value of HK10 and PIVKA-Ⅱ for diagnosing ovarian cancer were 2.74mg/L and 35.20U/L, respectively. The area under of the curve of the levels of HK10 combined with PIVKA-Ⅱ for predicting survival of the patients was 0.996. The critical values of HK10 and PIVKA-Ⅱ for predicting survival of the patients were 3.94mg/L and 37.96U/L, respectively. Conclusion: The diagnosis of ovarian cancer and the predicting death of the patients with ovarian cancer are significantly correlated with their serum HK10 and PIVKA-Ⅱ levels, which can be used as an important basis for diagnosing and evaluating the prognosis of ovarian cancer of the patients.
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