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Abstract To investigate the effects of different doses of hydromorone combined with ropivacaine for epidural labor analgesia of women, and to study its influence on the values of their SPO2, mean arterial pressure (MAP), and heart rate (HR). Methods: 120 full-term primiparas with single-fetus were selected and divided into four groups (30 cases in each group) by the principle of block randomization from September 2020 to April 2021. After epidural anesthesia, pulse automatic epidural pump was used for analgesia maintenance of the women in the four groups. And the parameters of automatic epidural pump included the analgesia drugs were diluted by 250 ml normal saline, the pulse dose was 8ml/h, the automatic analgesia dose was 6 ml/time, and the time was locked for 30 min. The women in group A were given 0.1% ropivacaine for analgesia maintenance. Except to the 0.1% ropivacaine given, the women in group B were given 5μg·ml-1 hydromorphone additionally, the women in group C were given 10μg·ml-1 hydromorphone additionally, and the women in group D were given 15μg·ml-1 hydromorphone additionally. The visual analog pain score (VAS), the onset time of anesthesia, the labor time, the values of MAP, SPO2, and HR at preanalgesia, post-analgesia 30min, and fetal delivery, Bromage score value at 30min after analgesia and delivery of the women, and the newborn Apgar score after birth were compared among the four groups. The safety of the drug used was also evaluated. Results: There was no significant difference in VAS scores at 10min, 30min, 2h, and 4h after labor analgesia, and the onset time of anesthesia of the women between group C and group D, but which of the women in group C and group D were all significantly lower than those of the women in group B and group A (P＜0.05). There were no significant differences in the durations of the first stages of labor, the second stages of labor, and the third stages of labor, and the values of MAP, SPO2, and HR of the women before analgesia, at 30min after analgesia, and at delivery, Bromage score of the women at 30min after analgesia and during delivery, and Apgar score of the newborn at 1 min and 5 min after birth, and the incidences of maternal nausea, vomiting, respiratory depression, and sedation score among the four groups (all P＞0.05). Conclusion: Hydromorphone (10μg/ml as recommended concentration) combined with ropivacaine for epidural labor analgesia has good effect.
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